THERAPEUTIC EFFICACY OF N-ACETYLCYSTEINE IN THE TREATMENT OF SUBCLINICAL ENDOMETRITIS IN GRADED MURRAH BUFFALOES (Bubalus bubalis)
| dc.contributor.advisor | SRINIVAS, M (MAJOR) | |
| dc.contributor.advisor | SADASIVA RAO, K | |
| dc.contributor.advisor | SREENU, M | |
| dc.contributor.author | AFREEN, FATHESHA | |
| dc.date.accessioned | 2021-07-30T06:08:10Z | |
| dc.date.available | 2021-07-30T06:08:10Z | |
| dc.date.issued | 2021-04 | |
| dc.description | THESES | en_US |
| dc.description.abstract | The present investigation was conducted to evaluate the efficacy of Enrofloxacin and N-acetylcysteine (Group I, n=12) and Enrofloxacin and normal saline (Group II, n=12) in the treatment of subclinical endometritis in Graded Murrah buffaloes. Buffaloes (n=60) presented with the history of repeat breeding were screened by per rectal examination of the genital tract, followed with assessment of cervico-vaginal mucus score and pH. Occurrence of symmetrical uterine horns with normal consistency and thick and heavy uterine horns with extra curvature based on per rectal examination was 56.67 (34/60) and 43.33 per cent (26/60), respectively. The 34 repeat breeder buffaloes with normal, symmetrical uterine horns were further screened for subclinical endometritis by assessment of cervico-vaginal mucus score, which revealed that 28 (82.35%) buffaloes showed clear mucus discharge of score 0. High proportion of buffaloes (60.71%) suspected for subclinical endometritis had the pH in the range of 7.5 to 8.0. The colour reaction upon white side test was recorded as light yellow colour noticed in 85.71 per cent (24/28) of buffaloes. The results showed that out of the 24 buffaloes evaluated for cytological evidence 20 (83.33%) buffaloes showed >10 to 18 per cent PMN, while 4 (16.67) showed >18 per cent PMN. Enrofloxacin had shown highest sensitivity (66.67%) upon ABST and it was selected for therapeutic trails by intrauterine route. Sensitivity of cytological evaluation of uterine discharges were superior over white side test as it could precisely estimate the clinical cure in 88.33% buffaloes as compared to 66.67% buffaloes by white side test. The uterine discharge metabolites, which showed significant reduction were urea (mg/dl) and urea nitrogen (mg/dl), whereas cholesterol (mg/dl) exhibited significant increase after treatment with intrauterine infusion of NAC. The recovery rates based on cytological evaluation of uterine discharge smear between the two treatment groups, revealed that Enrofloxacin and NAC (Group I) was superior with higher percentage of recovery (88.33% Vs 58.33%) over treatment with Enrofloxacin and normal saline (Group II). Higher conception rate was recorded with Enrofloxacin and 2% N-acetylcysteine (66.67%) compared to Enrofloxacin and normal saline (41.67%) in buffaloes treated for subclinical endometritis. In conclusion, combination of N-acetylcysteine with Enrofloxacin improved the clinical response and conception rate in buffaloes treated for subclinical endometritis. | en_US |
| dc.identifier.uri | https://krishikosh.egranth.ac.in/handle/1/5810171141 | |
| dc.keywords | GRADED MURRAH BUFFALOES; N-ACETYLCYSTEINE; SUBCLINICAL ENDOMETRITIS; THERAPEUTIC EFFICACY; TREATMENT | en_US |
| dc.language.iso | English | en_US |
| dc.pages | 159 | en_US |
| dc.publisher | SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA | en_US |
| dc.sub | Veterinary Gynaecology and Obstetrics | en_US |
| dc.theme | THERAPEUTIC EFFICACY OF N-ACETYLCYSTEINE IN THE TREATMENT OF SUBCLINICAL ENDOMETRITIS IN GRADED MURRAH BUFFALOES (Bubalus bubalis) | en_US |
| dc.these.type | M.V.Sc. | en_US |
| dc.title | THERAPEUTIC EFFICACY OF N-ACETYLCYSTEINE IN THE TREATMENT OF SUBCLINICAL ENDOMETRITIS IN GRADED MURRAH BUFFALOES (Bubalus bubalis) | en_US |
| dc.type | Thesis | en_US |