CYSTADENOCARCINOMA OF BARTHOLIN’S GLAND - HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY
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Date
2022
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Abstract
Bartholin’s glands are bilateral, mucussecreting,
tubuloacinar glands located within
the submucosa of the vulva of ruminants. Seven
years old graded Murrah buffalo was reported to
have vaginal prolapse. Clinical examination of the
vagina revealed a cyst like structure measuring
about 7x6 cm and seen on the Bartholin’s gland
and on incision it was pink, soft, and fluctuating.
The mass was removed as per the standard routine
surgical procedure. The mass had a thick wall and
contained about 100 ml of clear fluid. The inner
side revealed a rough surface and multiple soft
raised areas. Microscopical examination revealed
invasive, pleomorphic neoplastic epithelial cells
that formed irregular tubules and glands with
abundant fibrous stroma and inflammation. The
tubules were lined by single to double layered
eosinophilic anaplastic cuboidal to columnar cells.
The proliferated lining cells had large round to
oval vesicular nuclei and prominent nucleoli and
a few mitotic figures. Some glandular structures
were dilated and cystic or irregularly shaped.
Local invasion into the surrounding muscles was
noticed. Based on gross and histopathological
features the case was diagnosed as Bartholin’s
gland cystadenocarcinoma. Immunohistochemical
staining revealed strong positive reaction with
cytokeratin. After treatment, animal recovered
uneventfully and there was no recurrence.
Description
TNV_BUFBUL_2022_41(4)441-446
Keywords
Veterinary Science