INVESTIGATIONS ON HEPATIC DYSFUNCTIONS IN CANINE
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Date
2010-09-13
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CSKHPKV, Palampur
Abstract
The study was conducted on 894 dogs presented at Veterinary Clinical Complex
CSKHPKV, Palampur (H.P.). On the basis of history and clinical examination, dogs suspected
for hepatic dysfunction were subjected to haemato-biochemical examinations, radiography and
ultrasonography to confirm hepatic diseases. Among these, 26 dogs (2.91%) dogs with different
hepatic dysfunctions were diagnosed, out of which 80.77% were of primary liver disorders and
19.23% were of reactive hepatopathies. Among primary hepatopathies, the acute hepatitis
formed the largest group (57.69%) followed by cirrhosis (19.23%) and hepatitis with jaundice
(15.38%) and a single case (3.85%) of hepatic tumour. The mean age of dogs having primary
hepatic dysfunctions was higher (53.09 ± 9.23 months) than the dogs having reactive
hepatopathies (23.80 ± 7.94 months). The dogs suffering from liver dysfunctions showed
symptoms like inappetance/anorexia, ascites, vomition, dullness, constipation, fever, diarrhoea,
pale mucosa, jaundice, weight loss, melaena and weakness. Haematological examination
revealed significantly decreased haemoglobin and packed cell volume in primary hepatic
dysfunctions and neutrophilic leucocytosis in hepatitis and reactive hepatopathy. The mean
activities of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatse were
markedly higher in all the hepatic dysfunctions. Biochemical examination revealed
hypoproteinaemia and hypoalbuminaemia in primary hepatic dysfunctions. Ultrasonographic
studies were found very helpful in evaluation of liver status and classification of hepatopathies.
Following the combined therapy comprising hepatoprotectant (Silymarin), fluid therapy, liver
extract, antibiotic, antiemetic and diuretics, 60 per cent cases of hepatitis and 40 percent cases of
cirrhosis could be treated successfully.
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