Synthesis of some heterocyclic compounds using ecofriendly conditions and their bioevaluation
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Date
2018
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CCSHAU
Abstract
Coumarins, Chalcones, Pyrazoles and Imidazoles are versatile classes of heterocycles and
intermediates for the preparation of other organic compounds due to their variety of biological
activities. For the preparation of these compounds and their derivatives, different organic solvents and
reagents are being used which are quite hazardous to environment and human health due to their
volatile nature. Since last few years attempts are being made for ecofriendly synthesis viz. microwave
irradiation synthesis and synthesis by grinding methods. Therefore an attempt has been made to
synthesize above mentioned classes of compounds by grinding methods, aqua mediated methods and
microwave assisted methods. These compounds were characterized by spectroscopic techniques viz.
1HNMR, IR, Elemental analysis and other analytical data. Structure of the compounds were found
identical in all methods of synthesis i.e. conventional, grinding methods, aqua mediated methods and
microwave assisted method. Synthesized compounds were screened for their antifungal activity by
poison food technique at four different concentrations. Compounds 33 and 93 were found more active
against the tested fungi Rhizoctonia solani and Aspergillus niger with EC50 values 53.13 and
56.52μg/ml respectively.
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