Immunohistochemical Localisation of Cytokeratin and Vimentin Expression in the Experimentally Induced Rat Mammary Tumour
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Date
2018-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Veterinary Association
Abstract
The present study was designed to examine
the expression of cytokeratin (CK 8 and 18)
and vimentin in DMBA (7,12-dimethylbenz[a]
anthracene) induced rat mammary carcinogenesisby
immunohistochemical analysis. Twentyfour
female Sprague-Dawley rats were equally
distributed to form the control, DMBA, tamoxifen
(Standard drug) and Withaferin A groups.
Mammary tumours were collected on the 120th
day after initial dose of DMBA administration.
Increased cytoplasmic expression of cytokeratin
and vimentin were observed in all the DMBA
administered groups and oral administration of
Withaferin A did not reduce the tumour burden.
Description
TNV_IVJ_2018_95(4)76-78
Keywords
Veterinary Science