Effect of dietary ochratoxin on biochemical and antioxidant profile in broiler chickens
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Date
2014-11
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Poultry Science Association
Abstract
Twelve newly hatched broiler chicks were randomly allotted to two groups (Control -6 Nos. and 100 ppb ocharatoxin A (OA)
toxin fed group-6 birds) and maintained up to 28 days of days. On 28th day, all the birds from both the groups were sacrificed to study
the serum biochemical alterations and liver antioxidant profile. Significant (P<0.05) decrease was observed in the globulin and A:G ratio
in the OA fed group. Hypoglycaemia, hypoamylasaemia, reduction in HDL, elevation in ALT, ALP, BUN, triglycerides, VLDL and TC/
HDL ratio were observed in the OA fed group. No significant differences were observed between the control and OA fed group in the
total protein, albumin, AST, GGT, creatinine, uric acid, total cholesterol, LDL and lipase. TBaRs levels of liver were increased
significantly (P<0.05) in the OA fed group compared to the control group. SOD, catalase, GPx, GSH and GST levels were decreased
significantly (P<0.05) in the liver of OA fed birds compared to the control group. Biochemical alterations indicated the hepatocellular
damage, renal damage and alimentary tract pathology. Antioxidant profile revealed that hepatocellular degeneration and oxidative stress.
It was concluded that dietary dose of 100 ppb ochratoxin caused liver and kidney dysfunctions, hypoglycaemia, increased liver lipid
peroxidation and decreased antioxidant levels.
Description
TNV_IJPS_Y2014dnov_V49_I3_Pg331-333
Keywords
Veterinary Science