Arsenic decreases antinociceptive activity of paracetamol: Possible involvement of serotonergic and endocannabinoid receptors

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dc.contributor.authorVijayakaran, Karunakaran
dc.contributor.authorKesavan, Manickam
dc.contributor.authorKannan, Kandasamy
dc.contributor.authorSankar, Palanisamy
dc.contributor.authorTandan, Surendra Kumar
dc.contributor.authorSarkar, Souvendra Nath
dc.contributor.authorTANUVAS
dc.date.accessioned2018-06-05T11:08:16Z
dc.date.available2018-06-05T11:08:16Z
dc.date.issued2014
dc.descriptionTNV_ETP_2014_38(397-405)en_US
dc.description.abstractWe assessed whether repeated arsenic exposure can decrease paracetamol-mediated antinociception by modulating serotonergic and endocannabinoid pathways. Rats were preexposed to elemental arsenic (4 ppm) as sodium arsenite through drinking water for 28 days. Next day paracetamol’s (400 mg/kg, oral) antinociceptive activity was assessed through formalin-induced nociception. Serotonin content and gene expression of 5-HT1A, 5-HT2A and CB1 receptors were evaluated in brainstem and frontal cortex. Arsenic decreased paracetamol-mediated analgesia. Paracetamol, but not arsenic, increased serotonin content in these regions. Arsenic attenuated paracetamol-mediated increase in serotonin level. Paracetamol did not alter 5-HT1Aexpression, but caused down-regulation of 5-HT2Aand up-regulation of CB1 receptors. Arsenic down-regulated these receptors. However,paracetamol-mediated down-regulation of 5-HT2Awas more pronounced. Arsenic did not modify paracetamol’s effect on 5-HT1A expression, but reduced paracetamol - mediated down - regulation of 5-HT2A and reversed up-regulation of CB1 receptors. Results suggest arsenic reduced paracetamol-induced analgesia possibly by interfering with pronociceptive 5-HT2A and antinociceptive CB1 receptors.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810049236
dc.keywordsArsenic Paracetamol Antinociception 5-HT receptors, CB1 receptor Raten_US
dc.language.isoenen_US
dc.pages397-405en_US
dc.publisherElsevieren_US
dc.subjectVeterinary Scienceen_US
dc.titleArsenic decreases antinociceptive activity of paracetamol: Possible involvement of serotonergic and endocannabinoid receptorsen_US
dc.title.alternativeEnvironmental Toxicology and Pharmacologyen_US
dc.typeArticleen_US
dc.volume38en_US
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