Complete genome sequence analysis of canine Parvovirus new 2a variant strain isolated from a dog with severe haemarrogic gastroenteritis in South India
dc.contributor.author | Raja, P | |
dc.contributor.author | Parthiban, M | |
dc.contributor.author | Maha Prabhu, M; et al. | |
dc.contributor.author | TANUVAS | |
dc.date.accessioned | 2020-03-04T08:39:47Z | |
dc.date.available | 2020-03-04T08:39:47Z | |
dc.date.issued | 2020-02 | |
dc.description | TNV_20thMVC_PP_Feb-2020_OP03 | en_US |
dc.description.abstract | The canine parvovirus (CPV) infection is characterized by severe hemorrhagic gastroenteritis and myocarditis in dogs caused by different antigenic variants CPV-2a, CPV-2b, New CPV-2a, New CPV-2b and CPV-2c and these antigenic variants are evolved rapidly and completely replaced the original CPV-2 variants in throughout the world. In India, there are several reports even in vaccinated dogs with CPV infections in recent years and the predominant type of antigenic variant is CPV-2a. Here, we report a virulent field CPV-2a strain, ABT/CPV/MVC02, was isolated from a faecal sample of a dog with severe haemorrhagic gastroenteritis in Chennai, Tamil Nadu, India. The genome sequence of ABT/CPV/MVC02 was determined and analyzed to study the CPV-2 antigenic variants currently circulating in India. The genomic sequence of ABT/CPV/MVC02 comprises of 4495 nucleotides (nt) containing two open reading frames (ORFs). ORF1 (nt 1-2007) encoded two non structural proteins (NS1 and NS2), and ORF2 (nt 2014-4270) encoded two structural proteins (VP1 and VP2). The genome sequence of ABT/CPV/MVC02 shares 99.33% nucleotide identity with those of CPV new 2a variants (MH476591 and MH476580) strains and shares 99.20% and 98.98% nucleotide identity with JQ268284 (CPV 2b) and KU508407 (CPV 2c) strains respectively. There is one insertion site at VP1 region (nt- 2113) and two deletion sites were found at 3’ untranscribed region (UTR) (nt-4478 and 4481). The present study reveals that the ABT/CPV/MVC02 CPV-2a new variant strain circulating in India is evolving rapidly with unique variations at nucleotide level. Nucleotide sequence accession number: The genome sequence of new CPV-2a strain ABT/CPV/MVC 02 has been deposited in Gen Bank under the accession number MN661243. | en_US |
dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810144194 | |
dc.keywords | 20th Indian Veterinary Congress, Annual Conference of IAAVR, TANUVAS | en_US |
dc.language.iso | en | en_US |
dc.pages | 1 | en_US |
dc.subject | Veterinary Science | en_US |
dc.title | Complete genome sequence analysis of canine Parvovirus new 2a variant strain isolated from a dog with severe haemarrogic gastroenteritis in South India | en_US |
dc.title.alternative | National Symposium on Veterinary Research Priorities in Translational Animal Health, Production and Food Safety | en_US |
dc.type | Presentation | en_US |
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