PROTECTIVE EFFECT OF N-ACETYL CYSTEINE AGAINST ARSENIC-INDUCED TOXICITY IN RATS

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dc.contributor.advisorGOPALA REDDY, A(MAJOR)
dc.contributor.advisorUSHA RANI, M
dc.contributor.advisorANAND KUMAR, A
dc.contributor.advisorRAMANA REDDY, Y
dc.contributor.authorHEMALATHA, P
dc.date.accessioned2018-11-01T09:43:44Z
dc.date.available2018-11-01T09:43:44Z
dc.date.issued2010-06
dc.descriptionTHESESen_US
dc.description.abstractABSTRACT: N-acetyl cysteine was evaluated against arsenic-induced toxicity in rats. The Wistar rats were divided into 4 groups and treated as follows: Group 1: sham control, 2: arsenic control, 3: N-Acetyl cysteine (NAC) pre-treatment for two weeks followed by arsenic + NAC and 4: arsenic + NAC. Average body weights were recorded at weekly intervals and testes weights were recorded at the time of sacrifice. On 29th day, organs were collected for estimation of TBARS, protein carbonyls and GSH in tissue homogenates. Activity of Na+-K+ ATPase , Mg2+ATPase and CYP450 of liver, intra-testicular LDH, serum creatinine, and serum LDH were also estimated. Histopathology of heart, liver, kidney, testis, lung, intestine and stomach was also studied at the end. Body weight gain, relative testis weight, GSH, CYP450, Na+/K+ ATPase and Mg2+ATPase were significantly (P < 0.05) decreased, while TBARS, protein carbonyls, serum LDH, intra-testicular LDH and serum creatinine were significantly (P < 0.05) increased in group 2 as compared to other groups. Group 1 did not reveal any abnormalities on histopathology. Group 2 (arsenic control) showed marked degenerative changes in heart, kidney, liver, testis, lung, intestine and stomach. NAC-treated groups (3 and 4) showed improvement in all the parameters studied, though it was marked with NAC pre-treatment. From this study, it is concluded that arsenic induces toxicity to heart, kidney, liver, testis, lung, intestine and stomach, and these effects can be reverted by NAC administration.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810082680
dc.keywordsRATS;ARSENIC;PROTECTIVE EFFECT;N-ACETYL CYSTEINE;TOXICITYen_US
dc.language.isoenen_US
dc.pages157en_US
dc.publisherSRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIAen_US
dc.subVeterinary Pharmacology and Toxicologyen_US
dc.subjectnullen_US
dc.themePROTECTIVE EFFECT OF N-ACETYL CYSTEINE AGAINST ARSENIC-INDUCED TOXICITY IN RATSen_US
dc.these.typeM.V.Sc.en_US
dc.titlePROTECTIVE EFFECT OF N-ACETYL CYSTEINE AGAINST ARSENIC-INDUCED TOXICITY IN RATSen_US
dc.typeThesisen_US
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