Effect of Psidium guajava Leaves on Adenine Induced Chronic Kidney Disease in Rats

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dc.contributor.advisorIngole, R. S.
dc.contributor.authorAnandgaonkar Varad Amolrao
dc.date.accessioned2024-11-04T07:08:48Z
dc.date.available2024-11-04T07:08:48Z
dc.date.issued2024-03-02
dc.description.abstractThe present study was carried out to evaluate the nephroprotective effect of aqueous extract of Psidium guajava leaves in adenine induced chronic kidney disease (CKD) in rats. The extract was subjected to HR-LCMS analysis which revealed the presence of various flavonoids and polyphenolic bioactive compounds with potent antioxidant and anti-inflammatory activities. The study involved 5 groups of 8 male Wistar rats each labelled as Group I served as normal control group which received 0.5% CMC solution by gavage for 28 days. Group II kept as CKD control group and administered with adenine solution @100mg/kg b. wt. (1-28 days). Group III was gavaged with aqueous extract of guava leaves @300mg/kg b. wt. (1-28 days). Group IV simultaneously received adenine solution and aqueous extract of guava leaves @100mg/kg and 300mg/kg b. wt. respectively per orally for 1-28 days. Group V was administered with adenine solution @100mg/kg b. wt. for 1-28 days and then treated with aqueous extract of guava leaves @300mg/kg from 15-28 days. Rats of adenine intoxicated group showed clinical signs such as polyuria, polydipsia and dehydration. Adenine treated group II rats showed significant decrease in weekly feed intake and weekly body weight while significant increase in weekly water intake and mean and relative kidney weight. Significant decrease in Hb, PCV, TEC and lymphocyte count while significant increase in TLC and neutrophil count was observed in group II. Serum BUN, creatinine, AST, ALT and phosphorous levels elevated significantly while serum total protein, albumin, globulin and calcium was significantly decreased in group II rats. Group II showed significant increase in MDA while significant decline in SOD, CAT and GSH enzymes. Treatment with aqueous extract of Psidium guajava leaves significantly alleviated effects of adenine induced CKD with marked improvement in general performance, haematobiochemical and antioxidant parameters in group IV followed by group V. Grossly kidneys of the group II were significantly enlarged with extensive deposition of white crystals over the surface. Microscopically, kidney sections of group II showed profound histopathological changes characterized by loss of renal histoarchitecture with diffuse interstitial fibrosis which were mitigated in rats of groups IV and V. Thus, aqueous extract of Psidium guajava leaves showed nephroprotective effects in adenine induced chronic kidney disease in rats.
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810216007
dc.keywordsVeterinary Pathology
dc.keywordsguajava Leaves
dc.keywordsKidney Disease
dc.keywordsRat
dc.language.isoEnglish
dc.pages191
dc.publisherMAFSU, Nagpur
dc.subVeterinary Pathology
dc.themePsidium guajava Leaves on Adenine Induced Chronic Kidney Disease in Rats
dc.these.typeM.V.Sc.
dc.titleEffect of Psidium guajava Leaves on Adenine Induced Chronic Kidney Disease in Rats
dc.typeThesis
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