CLINICAL EVALUATION OF DIAZEPAMBUTORPHANOL OR ACEPROMAZINE-BUTORPHANOL FOR SEDATION DURING PROPOFOL HALOTHANE ANAESTHESIA IN DOGS
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Date
2013-07-08
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CSKHPKV, Palampur
Abstract
The purpose of this study was to evaluate the neuroleptanalgesic combination of
diazepam-butorphanol or acepromazine-butorphanol in propofol halothane anaesthesia.
Twenty clients owned dogs of either sex were randomly divided into two groups DP
(Diazepam-Propofol) and AP (Acepromazine-Propofol). All dogs were premedicated with
Inj. Atropine sulphate @ 0.04 mg/kg b. wt. followed fifteen minutes later with Inj.
Butorphanol tartarate @ 0.2 mg/kg b. wt IV. Subsequently after 10 minutes premedicated
with Inj. Diazepam @ 0.5 mg/kg b. wt IV or Inj. Acepromazine maleate @ 0.015 IV
followed by Inj. Propofol “till effect” IV for induction of surgical anaesthesia. After
induction having achieved, the animals were immediately transferred to halothane in
oxygen. Observations recorded in dogs included analgo-clinical observations,
cardiovascular observations, haemodynamic observations, anaesthetic response and dose,
pulmonary responses and haemato-biochemical observations at various time intervals.
Average induction dose of propofol in DP group was 5.11 mg/kg and 4.89 mg/kg
in DP and AP group respectively. Faster muscle relaxation and higher hypothermia was
observed in AP group. No arrhythmia, tachycardia and fall in arterial blood pressure were
observed in both the groups after induction. CVP, SPO2 and ETCO2 remained in
physiological limits in both anaesthetic combinations. Significant respiratory depression
occurred in both the groups after induction. Transient apnea was observed in three animals
in DP group and two in AP group. Apneas were resolved without any intervention.
Smoother induction and transfer were achieved by both combinations. Recoveries were
smoother, faster and excitement free in AP group. Significant fall in PCV and TEC
occurred in DP group in early phase whereas only PCV decreased significantly in AP
group. Biochemical parameters were non significant in both the groups.
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