Evaluation of Antitumor Potentials of Herbal Based Natural Products in Experimentally Induced Carcinogenesis In Silico and In Vitro

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dc.contributor.authorPreetha, S.P.
dc.contributor.authorPunniamurthy, N.
dc.contributor.authorBalachandran, C.
dc.contributor.authorCecilia, J.
dc.contributor.authorMangalagowri, A.
dc.contributor.authorSureshkannan, S.
dc.contributor.authorSujatha, P.L.
dc.contributor.authorTANUVAS
dc.date.accessioned2019-07-16T10:51:13Z
dc.date.available2019-07-16T10:51:13Z
dc.date.issued2016
dc.descriptionTNV_BM_7(1)_2016_4-10en_US
dc.description.abstractCancer has emerged as one of the most dreaded diseases of the 20th century, spreading further with continuance and increasing incidence in 21stcentury. Though chemoprevention has evolved as a promising and valuable strategy to inhibit, suppress or control the incidence of carcinogenesis, it is essential to explore the chemotherapeutic agents in experimental models before embarking on clinical trials. Experimental tumours have great importance for the purposes of modelling and Ehrlich Ascites Carcinoma (EAC) is one of the commonest since it is an undifferentiated carcinoma with rapid proliferation, high transplantable capability and bears similarities to human tumours. Natural products play a pivotal role in cancer therapy with substantial numbers of anticancer agents being natural or natural derived products with negligible side effects. The use of herbal based natural products may present an affordable and sustainable alternative to synthetic medicines. Acalyphaindica Linn. andTinosporacordifolia are used in Traditional System of Medicine and ethnoveterinary practices with multiple pharmacological activities. Keeping in view the importance and advantages of combination chemotherapy using herbal based natural products on the tumour cells, this study was attempted to explore the influence of combined extracts of Acalyphaindica and Tinosporacordifolia in experimentally induced carcinogenesis invitro. The utility and impact of herbal based natural products, the combined extracts of AcalyphaindicaandTinosporacordifolia in cancer chemotherapy, was tested on EAC cells. The Antitumor efficacy of the herbal based natural products was evaluated with relevant carcinogenesis indicators in Ethno Veterinary Herbal Research and Training Unit for Livestock Health Care, Thanjavur. The Combined extracts of Acalyphaindica and Tinosporacordifoliawas found to have potential anti cancer activity from the in silico and in vitro studies.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810114925
dc.keywordsVeterinary Science, Veterinary Parasitology, Antitumor, Carcinogenesis Interaction, Drug design, Acalyphaindicaisen_US
dc.language.isoen_USen_US
dc.pages4-10en_US
dc.relation.ispartofseries;1
dc.subjectVeterinary Scienceen_US
dc.subjectVeterinary Parasitologyen_US
dc.titleEvaluation of Antitumor Potentials of Herbal Based Natural Products in Experimentally Induced Carcinogenesis In Silico and In Vitroen_US
dc.title.alternativeBiomirroren_US
dc.typeArticleen_US
dc.volume7en_US
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