Clinical Signs, Activity Indices and Prognostic Indicators in Dogs with Idiopathic Inflammatory Bowel Disease
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Date
2023
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Abstract
Background: Canine inflammatory bowel disease (IBD) includes a set of diseases characterized by the presence of recurrent
gastrointestinal clinical signs and histologic evidence of intestinal inflammation. Diagnosis can only be made by excluding other
possible causes of enteritis. Since the diagnosis of this disease is of great challenge to the veterinarians and currently very little work
have been carried out in India, the present study was planned and conducted to study the clinicopathological changes and prognostic
indicators of idiopathic inflammatory bowel disease (IBD) in dogs.
Methods: After a detailed clinical, laboratoty and endoscopic examination, 33 IBD dogs with signs of chronic gastrointestinal disorders
and histologic evidence of mucosal lymphocytic plasmacytic infiltration were selected for the study.
Result: Moderate to severe form of IBD with haematochezia as a chief complaint was predominantly recorded. Haematobiochemical
changes were not remarkable except a rise in serum alkaline phosphatase level. Decreased IgA expression was observed in serum
by flowcytometry indicating impaired mucosal immunity in IBD dogs. It was observed that, increased clinical inflammatory bowel
disease activity index score (CIBDAI), increased C-Reactive Protein, decreased cobalamin and folate may act as negative predictors
in idiopathic IBD.