NUTRITIONAL PROFilE AND ANTIOXIDANT MICRONUTRIENT PRESCRIPTIVE APPROACH TOWARDS OESOPHAGEAll ORAL CANCER PATIENTS
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Date
2007-01-06
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University of Agricultural Sciences GKVK, Banglore
Abstract
oesophageal cancer patients, oral precancerous patients. With matched
, control. Further the efficacy of antioxidant chemoprevention in initiation,
promotion and progression phase of carcinogenesis and n u tritional
support system in cancer patients was studied, The mean intake of
nutrients and micronutrients were significantly lower in oral cancer
compared to matched control and oesophageal cancer except for thiamine
and riboflavin. The relative risk was higher with low intake of fruits, green
leafy vegetable, other vegetable, milk and milk products in both the
cancer groups. The circulating micronutrient level were significantly lower
in cancer group compared to control group except for magnesium. The
relative risk was higher with tobacco and alcohol in oesophageal and oral
cancer. Higher percentage of precancerous patients had poor quality of
diet. Higher relative risk was noticed with ~-carotene, ascorbic acid and
zinc intake. The mean body weight and food intake of animals in
carcinogen control group were significantly lower compared to other
group. The antioxidant enzyme levels were significantly higher with
antioxidant treatment group compared to carcinogen control. The
carcinogen control group animals reported malignancy histopathologically
whereas the treatment group animals were in preneoplastic stage. The
relative risk for precancerous was higher with green leafy and other
vegetables. After supplementation with synthetic antioxidant
micronutrient combinations Antoxid for 6 months significant increase' in
serum retinol level was recorded. About 40 per cent complete regression
of oral leukoplakia and 60 per cent partial regression was observed in
Antoxid intervention group. Low cost kitchen based enteral food was
formulated with malted grains, soy flour, pulse, skim milk powder and
dehydrated carrot powder, enriched with conditionally essential nutrients
and immunomodulators. The formula was well accepted and tolerated by
patients without any serious discomfort. There was improvement -with
body weight and other biochemical parameters on administration of food
for 30-45 days of enteral feeding on post operative patients
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