Design and synthesis of ESIPT based fluorescent probes for the sensing of potential analytes
Loading...
Date
2021-09
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
CCSHAU, Hisar
Abstract
Fluorescence sensing technology has been developed as a valuable tool in the field of medicinal chemistry, biochemistry and clinical diagnosis. The fluorescent probe is a key component in fluorescence sensing because of its ability to convert chemical events into observable signals, which is directly connected to sensitivity and selectivity. The present study describes the photophysical behavior and sensing application of the fused oxazoles using both theoretical and experimental techniques. Initially, the probes were synthesized via condensation reaction. After that, the ground state geometry of the synthesized probes was optimized using DFT based method. Then the effect of solvent was studied on the geometry of optimized compound. Along with this, the global reactivity parameters such as chemical potential, hardness, and electrophilicity index were also calculated using B3LYP and the 6-311(+)G level of theory. Using CPCM solvation model, the influence of solvent polarity was also investigated. Other phenomena such as AIQ, AIE, and solvatochromism were also explored for the synthesized probes. Finally, analyte detection was performed, and a selective detection of 2NP was observed in case of K1, with no effect of different metals on the emission profile.