3 D MODEL GENERATIONS OF BACTERIAL TOXINS

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dc.contributor.advisorMartha, Sushma Rani
dc.contributor.authorMajumdar, Sayantika
dc.date.accessioned2017-01-09T14:08:24Z
dc.date.available2017-01-09T14:08:24Z
dc.date.issued2011
dc.description.abstractProteins are key biological molecules with diverse functions. They take part in maintaining the structural integrity of the cell, transport and storage of small molecules, catalysis, regulation, signaling and the immune system. Linear protein molecules fold up into specific three-dimensional structures, and their functional properties depend intricately upon their structures. It is a great challenge for nowadays biologists to predict the three- dimensional structure of a protein from its linear sequence. Proteins, amino acid chains, are made up from 20 different amino acids that are folded into unique three-dimensional protein structures. These structures are determined by their sequence of amino acids. Bacterial toxins continue to impose a major threat to public health worldwide in the 21st century. Information on bacterial toxin is important for molecular cell biology, proteomics and system biology and drug discovery. Intensified studies on bacterial toxins have greatly expanded our knowledge about the mechanisms of the disease processes at the molecular level over the last decades. Thus the ultimate goal of protein modeling of bacteria toxins is to predict a structure from its sequence with accuracy. These would allow users to safely use rapidly generated Insilco protein models in all the contexts where today only experimental structures provide a solid basis: structure-based drug design, analysis of protein function, interactions, antigenic behavior, and rational design of proteins with increased stability or novel functions. These models are the only way to obtain structural information if experimental techniques fail. To provide the structural information of bacteria toxins that are not present in PDB, prediction of those protein structures becomes necessary. This report contains 30 three dimensional protein models of bacteria toxins. Using these modeled structures; one can easily get some bit of information.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/95169
dc.language.isoenen_US
dc.relation.ispartofseriesTh;138
dc.subBioinformaticsen_US
dc.these.typeM.Sc
dc.title3 D MODEL GENERATIONS OF BACTERIAL TOXINSen_US
dc.typeThesisen_US
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