COMPARATIVE EVALUATION OF INTRADERMAL AND SUBCUTANEOUS PROPHYLACTIC RABIES VACCINATION IN DOGS

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dc.contributor.advisorVinodkumar K
dc.contributor.authorSEEMANTHINI R
dc.date.accessioned2019-08-03T04:35:13Z
dc.date.available2019-08-03T04:35:13Z
dc.date.issued2015
dc.description.abstractThe effectiveness of pre exposure prophylaxis against rabies in dogs by using inactivated tissue culture rabies vaccine administered through subcutaneous and intradermal route was compared. Twenty healthy, unvaccinated pups of age group 10 to 12 weeks brought to Teaching Veterinary Complex, Mannuthy and University Veterinary Hospital, Kokkalai were selected for the study under informed consent from the owners. Health status of pups was ascertained by clinical and haematological evaluation. Owners were advised to provide uniform environment and practice identical feeding practices as far as possible. On day 0, Group I were given one dose of inactivated tissue culture rabies vaccine through subcutaneous route by hypodermic needle and group II were given total of one-tenth dose of inactivated tissue culture rabies vaccine on medial aspect of each ear pinnae through intradermal route by using an instrument called DermojetR. Booster dose was administered for both the groups on day 30. Serum samples were collected on days 0, 15, 30, 45 and 180 post vaccination. The serum neutralizing antibody titres were assessed by Rapid fluorescent antibody test (RFFIT). All animals were having insignificant antibody titre by day 0. There was no significant difference in production of neutralizing antibodies between subcutaneous and intradermal groups after both primary and booster vaccinations. Animals in both the groups developed protective titre as early as day 15. Even though antibody peaked at 45th day, there was no statistically significant difference between 30th and 45th day of both the groups. Decline in antibody titre was evident after 45 days in both groups, but protective antibody titre was maintained all through the study period of 180 days in both groups. It is concluded that intradermal route of vaccination offered better economic prospects since similar antibody levels were produced and maintained with one-fifth dose of vaccine.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810118846
dc.keywordsCOMPARATIVE EVALUATION INTRADERMAL, SUBCUTANEOUS PROPHYLACTIC RABIES VACCINATION DOGSen_US
dc.language.isoenen_US
dc.pages87en_US
dc.publisherCOLLEGE OF VETERINARY AND ANIMAL SCIENCES-MANNUTHY,THRISSURen_US
dc.research.problemCOMPARATIVE EVALUATION OF INTRADERMAL AND SUBCUTANEOUS PROPHYLACTIC RABIES VACCINATION IN DOGSen_US
dc.subPreventive Veterinary Medicine and Epidemiologyen_US
dc.subjectnullen_US
dc.themeCOMPARATIVE EVALUATION OF INTRADERMAL AND SUBCUTANEOUS PROPHYLACTIC RABIES VACCINATION IN DOGSen_US
dc.these.typeM.V.Sc.en_US
dc.titleCOMPARATIVE EVALUATION OF INTRADERMAL AND SUBCUTANEOUS PROPHYLACTIC RABIES VACCINATION IN DOGSen_US
dc.typeThesisen_US
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