COMPARATIVE EVALUATION OF INTRADERMAL AND SUBCUTANEOUS PROPHYLACTIC RABIES VACCINATION IN DOGS
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Date
2015
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COLLEGE OF VETERINARY AND ANIMAL SCIENCES-MANNUTHY,THRISSUR
Abstract
The effectiveness of pre exposure prophylaxis against rabies in dogs by using
inactivated tissue culture rabies vaccine administered through subcutaneous and
intradermal route was compared. Twenty healthy, unvaccinated pups of age group
10 to 12 weeks brought to Teaching Veterinary Complex, Mannuthy and University
Veterinary Hospital, Kokkalai were selected for the study under informed consent
from the owners. Health status of pups was ascertained by clinical and
haematological evaluation. Owners were advised to provide uniform environment
and practice identical feeding practices as far as possible. On day 0, Group I were
given one dose of inactivated tissue culture rabies vaccine through subcutaneous
route by hypodermic needle and group II were given total of one-tenth dose of
inactivated tissue culture rabies vaccine on medial aspect of each ear pinnae through intradermal route by using an instrument called DermojetR. Booster dose was
administered for both the groups on day 30. Serum samples were collected on days
0, 15, 30, 45 and 180 post vaccination. The serum neutralizing antibody titres were
assessed by Rapid fluorescent antibody test (RFFIT). All animals were having
insignificant antibody titre by day 0. There was no significant difference in
production of neutralizing antibodies between subcutaneous and intradermal groups
after both primary and booster vaccinations. Animals in both the groups developed protective titre as early as day 15. Even though antibody peaked at 45th day, there was no statistically significant difference between 30th and 45th day of both the
groups. Decline in antibody titre was evident after 45 days in both groups, but
protective antibody titre was maintained all through the study period of 180 days in
both groups. It is concluded that intradermal route of vaccination offered better
economic prospects since similar antibody levels were produced and maintained with
one-fifth dose of vaccine.
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