Regioselective elaboration of isatin and their biological activity studies

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dc.contributor.advisorUtreja, Divya
dc.contributor.authorKomalpreet Kaur
dc.date.accessioned2021-09-09T06:47:28Z
dc.date.available2021-09-09T06:47:28Z
dc.date.issued2021
dc.description.abstractRegioselective elaboration of isatin at N-1 and C-3 position were carried out using different reagents. The synthesized isatin derivatives (2a-g and 4a-f) were characterized by 1HNMR, 1 HNMR-D2O, 13CNMR, FT-IR spectroscopies, mass spectrometery and elemental analysis. In vitro biological evaluation of synthesized isatin derivatives as antioxidant, antimicrobial and nematicidal agents had been carried out. The antioxidant evaluation using different models revealed that the compounds 1-decyl-indoline-2,3-dione (2g) and 3-heptyl-3-hydroxyindolin-2-one (4f) exhibited potent antioxidant potential due to the increase of electron donating character. The antimicrobial and nematicidal activity against Pseudomonas aeruginosa, Pseudomonas oryzihabitans, Xanthomonas campestris and Meloidogyne incognita pathogenic organisms revealed that the compounds isatin (1), 1-propyl-indoline-2,3-dione (2a) and 3-ethyl-3-hydroxyindolin-2-one (4a) exhibited potent inhibition potential against these pathogenic organisms as compared to other tested compounds. The in vitro results were further validated through in vivo studies on tomato and in silico studies which revealed that the tested compounds during investigation had shown novel interaction with the target binding sites and resulted in potent biological activity.en_US
dc.identifier.citationKomalpreet Kaur (2021). Regioselective elaboration of isatin and their biological activity studies (Unpublished Ph.D. Dissertation). Punjab Agricultural University, Ludhiana, Punjab, India.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810175554
dc.keywordsIsatin, N-alkylation, 3-hydroxy-3-alkylindolin-2-ones, Antioxidant, Antimicrobial, Nematicidal, in silico, in vivoen_US
dc.language.isoEnglishen_US
dc.pages217en_US
dc.publisherPunjab Agricultural University, Ludhianaen_US
dc.research.problemRegioselective elaboration of isatin and their biological activity studiesen_US
dc.subChemistryen_US
dc.themeRegioselective elaboration of isatin and their biological activity studiesen_US
dc.these.typePh.Den_US
dc.titleRegioselective elaboration of isatin and their biological activity studiesen_US
dc.typeThesisen_US
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