Regioselective elaboration of isatin and their biological activity studies
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Date
2021
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Punjab Agricultural University, Ludhiana
Abstract
Regioselective elaboration of isatin at N-1 and C-3 position were carried out using different
reagents. The synthesized isatin derivatives (2a-g and 4a-f) were characterized by 1HNMR,
1
HNMR-D2O, 13CNMR, FT-IR spectroscopies, mass spectrometery and elemental analysis. In vitro
biological evaluation of synthesized isatin derivatives as antioxidant, antimicrobial and nematicidal
agents had been carried out. The antioxidant evaluation using different models revealed that the
compounds 1-decyl-indoline-2,3-dione (2g) and 3-heptyl-3-hydroxyindolin-2-one (4f) exhibited
potent antioxidant potential due to the increase of electron donating character. The antimicrobial
and nematicidal activity against Pseudomonas aeruginosa, Pseudomonas oryzihabitans,
Xanthomonas campestris and Meloidogyne incognita pathogenic organisms revealed that the
compounds isatin (1), 1-propyl-indoline-2,3-dione (2a) and 3-ethyl-3-hydroxyindolin-2-one (4a)
exhibited potent inhibition potential against these pathogenic organisms as compared to other tested
compounds. The in vitro results were further validated through in vivo studies on tomato and in
silico studies which revealed that the tested compounds during investigation had shown novel
interaction with the target binding sites and resulted in potent biological activity.
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Citation
Komalpreet Kaur (2021). Regioselective elaboration of isatin and their biological activity studies (Unpublished Ph.D. Dissertation). Punjab Agricultural University, Ludhiana, Punjab, India.