Synthesis of benzylidene derivatives using green methods and their microbial activity
| dc.contributor.advisor | Sharma, Sunita | |
| dc.contributor.author | Verma, Diksha | |
| dc.date.accessioned | 2018-10-14T05:07:11Z | |
| dc.date.available | 2018-10-14T05:07:11Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Schiff bases are the condensation products of aldehydes and amines. Compounds (I-VII) have been synthesized by reacting 4-amino-1,2,4-triazole with different substituted benzaldehydes i.e. 4-bromobenzaldehyde, 4-nitrobenzaldehyde, furfuraldehyde, cinnamaldehyde, 4-N,N¢- dimehylaminobenzaldehyde, 4-N,N¢-diethylaminobenzaldehyde and 2,5- dimethoxybenzaldehyde using two different acidic catalysts i.e. tamarind extract and glacial acetic acid. These Schiff bases were also synthesized using conventional and microwave irradiation method. Microwave irradiation method proved to be time efficient and economical for the synthesis of Schiff bases. It was also observed that glacial acetic acid was best acid catalyst as compared to tamarind extract in aspects of yield and reaction time as former afford much higher yield and reaction got completed in much shorter time. As the catalytic amount of both the catalyst increased, the yield of corresponding Schiff bases increased. Antimicrobial activity of synthesized compounds against Pseudomonas aeruginosa, Klebsiella sp, and Enterobacter sp. revealed that Compound (II) was most effective with lowest MIC value against Klebsiella sp. None of the compounds was as effective as standard ampicillin. All the synthesized compounds differed significantly among themselves at all the test concentrations. | en_US |
| dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810081055 | |
| dc.keywords | Schiff bases, 4-amino-1,2,4-triazole, tamarind extract, glacial acetic acid, zone of inhibition, minimum inhibition concentration | en_US |
| dc.language.iso | en | en_US |
| dc.pages | 74 | en_US |
| dc.publisher | Punjab Agricultural University, Ludhiana | en_US |
| dc.research.problem | Synthesis of benzylidene derivatives using green methods and their microbial activity | en_US |
| dc.sub | Chemistry | en_US |
| dc.subject | null | en_US |
| dc.theme | Synthesis of benzylidene derivatives using green methods and their microbial activity | en_US |
| dc.these.type | M.Sc | en_US |
| dc.title | Synthesis of benzylidene derivatives using green methods and their microbial activity | en_US |
| dc.type | Thesis | en_US |