Synthesis of benzylidene derivatives using green methods and their microbial activity
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Date
2018
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Punjab Agricultural University, Ludhiana
Abstract
Schiff bases are the condensation products of aldehydes and amines. Compounds (I-VII) have
been synthesized by reacting 4-amino-1,2,4-triazole with different substituted benzaldehydes
i.e. 4-bromobenzaldehyde, 4-nitrobenzaldehyde, furfuraldehyde, cinnamaldehyde, 4-N,N¢-
dimehylaminobenzaldehyde, 4-N,N¢-diethylaminobenzaldehyde and 2,5-
dimethoxybenzaldehyde using two different acidic catalysts i.e. tamarind extract and glacial
acetic acid. These Schiff bases were also synthesized using conventional and microwave
irradiation method. Microwave irradiation method proved to be time efficient and economical
for the synthesis of Schiff bases. It was also observed that glacial acetic acid was best acid
catalyst as compared to tamarind extract in aspects of yield and reaction time as former afford
much higher yield and reaction got completed in much shorter time. As the catalytic amount
of both the catalyst increased, the yield of corresponding Schiff bases increased.
Antimicrobial activity of synthesized compounds against Pseudomonas aeruginosa,
Klebsiella sp, and Enterobacter sp. revealed that Compound (II) was most effective with
lowest MIC value against Klebsiella sp. None of the compounds was as effective as standard
ampicillin. All the synthesized compounds differed significantly among themselves at all the
test concentrations.
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