Antigenotoxic Effect of Nano-quercetin on 7,12-dimethylbenz[a]anthracene Induced Genotoxocity in Sprague Dawley Rats
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Date
2019
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Abstract
Agents that inhibit DNA adduct formation,
stimulate DNA repair mechanisms and possess
antioxidant functions are considered antigenotoxic
agents. An investigation was undertaken
as the antigenotoxic effect of quercetin and nanoquercetin
against 7,12 dimethylbenz[a]anthracene
(DMBA) induced genotoxicity by analysing
the frequency of micronucleated polychromatic
erythrocytes (MnPCEs). Elevated MnPCEs
frequency was observed in DMBA group. Treatment
with quercetin and nano-quercetin reduced
the frequency of micronucleus formation. It was
*Part of the M.V.Sc., thesis of the rst author submitted to the
TANUVAS, Chennai-51.
1Corresponding author: Email : shahanaabi148@gmail.com
R.Thangadurai and P.S.Shanmugam
The Indian Veterinary Journal 36 (December, 2019)
demonstrated that nano-quercetin reduced the
micronucelus frequency against DMBA induced
genotoxicity in the female Sprague Dawley rats.
Description
TNV_IVJ_2019_96(12)35-37
Keywords
Veterinary Science