Evaluation of Therapeutic Potential of Certain Homeopathic Preparations in Canine Atopic Dermatitis

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dc.contributor.advisorSingh, Shanker Kumar
dc.contributor.authorChaudhary, Sujeet Kumar
dc.date.accessioned2020-12-24T05:47:26Z
dc.date.available2020-12-24T05:47:26Z
dc.date.issued2018-08-17
dc.descriptionEvaluation of Therapeutic Potential of Certain Homeopathic Preparations in Canine Atopic Dermatitisen_US
dc.description.abstractCanine atopic dermatitis (CAD) in dogs is a multifactorial geneticallypredisposed inflammatory and pruritic skin disease with characteristic clinical features that is associated with IgE antibodies. A dysregulation of cutaneous immune system which favours an acute T-lymphocyte helper type-2 (Th2) pro-inflammatory reaction to allergens has recently been documented. The release of many pro-inflammatory cytokines after allergen exposure is now considered to be the key to the allergic response. Glucocorticoids (GCs) (prednisone, prednisolone, methylprednisolone) are considered to be the first line of sole therapy to manage CAD. However, GCs have potential detrimental side effects on the health of treated dogs and are not considered to be safe on prolong use. The dog-owning public is now more interested in “natural” and “alternative” methods of disease management. Albeit, homeopathic preparations are being used as alternative medicines since long, the scientific validation of their efficacy and mechanism of action in animal’s skin diseases is still in infancy. Hence, the present study aimed to evaluate the efficacy of homeopathic preparations for clinical recovery and immuno-regulatory potential in dogs with AD. The dogs with atopic dermatitis were allocated into four groups of six dogs in each one. Dogs of Group 1 were treated with prednisolone; Group 2 were treated with Sulphur 200 C; Group 3 were treated with Psorinum 200 C and Group 4 were treated with the combination Sulphur 200C and Psorinum 200 C. All homeopathic medicines were given at a dose rate of 3-5 drops, three times in a day orally for 60 days. Dogs with AD revealed remarkable alterations in the leukograms in comparison to healthy controls. Remarkable elevations in circulatory inflammatory cytokines (IL-17 and IL31) and total Ig-E levels were observed in dogs with AD. Atopic dogs treated with prednisolone and Psorinum + Sulphur revealed significantly amelioration of the altered haemato-biochemical panels. Similarly, these dogs also found to have significant reduction in circulatory pro-inflammatory cytokines (IL-17 & IL-31) and Ig-E levels at day 60 post-therapy as compared with their own day 0. Marked reduction in clinical scores (CADLI and VAS) of atopic dermatitis were revealed by the atopic dogs when treated with Sulphur alone and in combination with Psorinum at days 30 and 60 post-therapy as compared with day 0 scores. No adverse effects were observed in any of the homeopathy treated dogs. Therefore, it can be concluded that dogs with AD have a marked alterations in leukograms with eosinophilia. Remarkable elevation in circulatory pro-inflammatory cytokines (IL-17 and IL-31) and Ig-E might be associated with immuno-pathogenesis of canine atopic dermatitis. Combination of Psorinum 200 C and Sulphur 200 C could be a novel potent therapeutic agent for management of CAD. These preparations also have potential to heal the skin lesions of dogs with AD and have almost equivalent therapeutic potential to that of standard glucocorticoid. The homeopathic preparations; Psorinum 200 C and Sulphur 200C are quite safe and superior over prednisolone for long term therapy and have excellent potential to ameliorate the immunological aberration of dogs with AD and can cure the dermatological lesions of AD from the root in diseased dogs.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810157204
dc.keywordsEvaluation , Therapeutic Potential of Certain Homeopathic Preparations in Canine Atopic Dermatitisen_US
dc.language.isoEnglishen_US
dc.pages166en_US
dc.publisherU.P. Pandit Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, (DUVASU), Mathura – 281001en_US
dc.research.problem1. To evaluate the efficacy of certain homeopathic preparations for clinical recovery in dogs with AD. 2. To evaluate the immuno-regulatory potential of certain homeopathic preparations in dogs with AD.en_US
dc.subVeterinary Medicineen_US
dc.themeCanine atopic dermatitis (CAD) in dogs is a multifactorial geneticallypredisposed inflammatory and pruritic skin disease with characteristic clinical features that is associated with IgE antibodies. A dysregulation of cutaneous immune system which favours an acute T-lymphocyte helper type-2 (Th2) pro-inflammatory reaction to allergens has recently been documented. The release of many pro-inflammatory cytokines after allergen exposure is now considered to be the key to the allergic response. Glucocorticoids (GCs) (prednisone, prednisolone, methylprednisolone) are considered to be the first line of sole therapy to manage CAD. However, GCs have potential detrimental side effects on the health of treated dogs and are not considered to be safe on prolong use.en_US
dc.these.typeM.V.Sc.en_US
dc.titleEvaluation of Therapeutic Potential of Certain Homeopathic Preparations in Canine Atopic Dermatitisen_US
dc.typeThesisen_US
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