Assessment of antioxidant and anti-inflammatory potential of ten selected conventional medicinal plant species
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Date
2018-07
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G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand)
Abstract
Regardless of the advent of modern high throughput drug discovery and screening procedures, traditional medicine remains as the most affordable source of treatment with minimal side effects. In this regard, antioxidants inhabiting the plant tissues have become a major area of research as they are known to sufficiently stable free radicals and neutralize them. In the present study, ten conventional medicinal plant species were selected to assess their antioxidant and anti-inflammatory potential. In all selected plant species, the yield, antioxidants and anti-inflammatory activities were comparatively higher in methanol than in acetone extracts. In both methanol and acetone, DPPH activity (%) was maximum in Ziziphus mauritiana (91.93and 81.49) and FRAP (μg TE/mg) in Ocimum gratissimum (132.74 and 89.18, respectively); whereas TAA (μg VCE/mg) was highest in Z. mauritiana (293.18) in methanol and Achyranthes aspera (77.56) in acetone. The IC50 values (μg/ml) of Bauhinia variegate (70.51) and Z. mauritiana (60.14) were close to BHT (57.38). The TPC (μg GAE/mg) was highest in Z. mauritiana (98.54) and B. variegata (48.76) in methanol and acetone, respectively; while TFC (μg QE/mg) was maximum in Alternanthera ficoidea (25.23±012 in methanol and 19.35±0.27 in acetone). Anti-inflammatory potential against albumin denaturation (%) was comparatively higher in O. gratissimum in both methanol (35.12) and acetone (29.26) than other species. Furthermore, positive correlation was obtained between TPC-DPPH, TPC-FRAP and DPPH-FRAP, while other combinations showed no correlation. Thus, the present findings lay a scientific foundation that the above plant species with comparatively higher antioxidant and anti-inflammatory potential can be utilized by pharmaceutical and nutraceutical industries for developing natural curative and dietary substitutes against synthetic ones with boundless availability.
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