In vitro cytotoxicity of zinc oxide, iron oxide and copper nanopowders prepared by green synthesis

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dc.contributor.authorSaranya, S
dc.contributor.authorVijayarani, K
dc.contributor.authorPavithra, S, et al.
dc.contributor.authorTANUVAS
dc.date.accessioned2020-02-10T09:04:48Z
dc.date.available2020-02-10T09:04:48Z
dc.date.issued2017
dc.descriptionTNV_TR_2017_4_427-430en_US
dc.description.abstractIn vitro cytotoxic effects of ZnO, FeO and Cu metallic nanopowders (NPs) on Vero (African green monkey kidney cell line), PK 15 (Pig kidney cell line) and Madin Darby Bovine Kidney (MDBK) cell lines were investigated at different time intervals (24 and 48 h). MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to determine the cytotoxic effects of green synthesized (plant based) nanopowders. The comparative effects of exposure period and concentration of nanopowders on cell viability were studied. Green synthesized nanopowders showed varying activity on different type of cells and the effect was generally based on the concentration and exposure time. In MDBK cells, only ZnO nanopowder (NP) showed significant effect on cell viability. The ZnO NP showed improved cell viability at lower concentration (10 μg/100 μl) in all type of cells (Vero, PK 15 and MDBK cells). In contrast, FeO NP showed better activity at the concentration of 10 μg/ 100 μl, 50 μg/100 μl and 40 μg/100 μl after 24 h exposure time in Vero, PK 15 and MDBK cells respectively. However better cell viability was observed in Cu NP treated Vero, PK 15 and MDBK cells at 40 μg/100 μl, 20 μg/ 100 μl and 10 μg/100 μl correspondingly. These studies suggested that the activity of green synthesized NPs were highly dependent on concentration, exposure time and type of cells.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810142790
dc.keywordsKeywords: ZnO FeO Cu Nanopowders MTT in vitro cytotoxicityen_US
dc.language.isoenen_US
dc.pages427-430en_US
dc.subjectVeterinary Scienceen_US
dc.titleIn vitro cytotoxicity of zinc oxide, iron oxide and copper nanopowders prepared by green synthesisen_US
dc.title.alternativeToxicology Reportsen_US
dc.typeArticleen_US
dc.volume4en_US
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