PHARMACOLOGICAL EVALUATION OF NANO-QUERCETIN ONFLUORIDE INDUCED CARDIOVASCULAR TOXICITY IN WISTAR RATS
Loading...
Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
TANUVAS, CHENNAI
Abstract
The study was conducted to evaluate the pharmacological effect of nano-quercetin (NQC) on sodium fluoride (NaF) induced cardiovascular toxicity in Wistar rats.
For the study undertaken, thirty six male Wistar rats were divided into six groups by randomization procedure. The group I served as negative control whereas group II was kept as positive control (Fluoride). All the groups except group I were given 100ppm of NaF in drinking water ad libitum for 42 days. Group III was treated with QC 50mg/kg body weight daily by oral gavage for 42 days. Group IV was treated with NQC 25mg/kg body weight by oral gavage for 42 days. Group V was treated with QC 100mg/kg body weight by oral gavage in the last 14 days of the trial i.e., starting from the 29th to the 42nd day. Group VI was treated with NQC 50mg/kg body weight by oral gavage for the last 14 days of the trial.