IN SILICO APPROACHES TO STUDY THE EFFECT OF A1 AND A2 MILK VARIANTS ON TYPE 1 DIABETES MELLITUS INCIDENCE
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
TANUVAS
Abstract
Cow’s milk [3-casein is a protein product of CSN2 gene, containing 209 amino
acids. There arc many genetic variants of β-casein among which Al and A2 are
recurrent which differs only by the presence of histidine in Al and proline in A2
variant at position 67. Due to the presence of histidine, the Al variant is more
susceptible to the enzymatic digestion. As a consequence of this enzymatic digestion
in the gastrointestinal tract, a bioactive peptide of 7 amino acids known as β-casomorphin 7 (BCM7), is released and absorbed in infants, as their gastrointestinal tract is more permeable As the name indicates, BCM7 elicit an opiate-like activity.
Description
TNV_TH_2016_DBI15001
Keywords
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