Comparison of Pharmacokinetics of Enrofloxacin After Single Oral Bolus and Pulse Dose Administration in Broiler Chicken
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Date
2017-07
Journal Title
Journal ISSN
Volume Title
Publisher
Council of the National Academy of Sciences
Abstract
Enrofloxacin was administered to commercial
broiler chicken of 6 weeks of age at 10 mg kg-1 as oral bolus and
pulse dose to two groups of twelve birds each. Blood was collected
at predetermined time interval and plasma samples were
analyzed for enrofloxacin concentration by using HPLC. Mean
plasma concentration was significantly higher in oral bolus dose
up to 2 h and at 48 h. In both the groups enrofloxacin concentration
was above 0.30 lg mL-1 up to 24 h. Pharmacokinetic
parameterswere calculated by non compartmental analysiswhich
revealed significant increase in AUC0–? (25.35 ± 1.92 vs.
19.66 ± 1.68 lg h mL-1) and t1/2b (10.63 ± 0.35 vs.
8.70 ± 0.74 h) in oral bolus dose when compared to pulse dose.
There was no significant difference in other pharmacokinetic
parameters such asMRT,MAT,Vd area/F,Vdss/F,ClB/F,Cmax and
tmax. Hence it can be concluded that enrofloxacin administered to
broiler chicken at 10 mg kg-1 every 24 h as pulse dosewill result
in better clinical efficacy at par with oral bolus dose.
Description
TNV_PNAS_2017_87(3)679–683
Keywords
Veterinary Science