HYPOLIPlDEMlC EFFECT OF Tinospora cordifolla IN DIET INDUCED HYPERLIPIDEMIC RATS
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Date
2005-12
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
ABSTRACT:
Present study was conducted to assess the hypolipidemic action
of aqueous and alcoholic extracts of Tinosporn cordifoolia roots and
compared the same with that of lovastatin and Vitamin E, on biochemical
and histo-pathological patterns in diet induced hyperlipidemic rats.
Forty-eight male albino rats weighing around 150 gm were divided
into 6 groups of eight in each. Group I served as control. Group 11,111, IV,
V and VI received experimental hyperlipidemic diet. Group 111 received
lovastatin @ 30 mgKg body weight. Group IV, V received aqueous and
alcoholic extracts of Tinospora cordiyoIia roots respectively @ 5g/ Kg
body Wt. Group VI received vitamin E @ 60 mg /Kg body Wt.
The serum lipid parameters w,HD L, LDL and TG] and
erythrocyte antioxidant enzymes [GPx, GSH- R] were monitored at day
14,28 and 42. At the end of day 42, animals were sacrificed and liver and
aorta samples were collected for histo-pathological examination.
Administration of hyperlipidemic diet resulted in increase of lipid
parameters like TC, LDL, and TG and decrease of HDL
The erythrocyte antioxidant enzyme [GPx, GSH- R] levels of whole
blood were significantly pSO.05] increased in T. cordifolia aqueous and
alcoholic extracts treated groups. Both alcoholic and aqueous extracts of
T cordifoolia ameliorated the hyperlipidemic effects of group I1 by
restoring the biochemical [TC, HDL, LDL and TG] and histopathological
changes to normal. Hypolipidemic effect of groups IV and V was similar
to group 111. Vitamin E treated group significantly increased the levels of
erythrocyte antioxidant eniynes but showed less action on lipid
parameters.
It is concluded that aqueous and alcoholic extracts of T.cordifoolia
roots could act as hypolipidemic agents in diet induced hyperlipidemic
rats.
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