EFFECT OF Cicer arientinum L. (BENGALGRAM) AGAINST HYPERLIPIDEMIAS IN OVARIECTOMIZED RATS
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Date
2010-07
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Sri Venkateswara Veterinary University, TIRUPATI – 517 502,A.P
Abstract
ABSTRACT :
Experimental studies were conducted to evaluate the ameliorating effects of germinated Cicer arientinum (Bengalgram seeds) in ovarian hormone deficiency induced hyperlipidemia and its effect was compared with atorvastatin.
Twenty four female wistar rats were divided into four groups i.e., group I – normal control (sham operated), group II – ovariectomized rats (OVX), group III – OVX+Bengalgram (20% germinated seeds in diet-II) and group IV – OVX+Atorvastatin (1.2 mg/kg b.wt p.o.). Body weights were taken at weekly interval. Blood was collected on day 14, 28, 42, and 56 for the estimation of serum Lipid profile and glucose. At the end of the experimental period, the rats were sacrificed and organs were collected and weighed. Liver lipid profile was studied and liver, aorta and uterine samples were collected for histopathological examination. There was a significant (p<0.05) increase in the serum total cholesterol and non-HDL cholesterol in group II than other groups and serum HDL concentrations significantly (p<0.05) increased in groups III and IV w.r.t group II. The triglyceride levels were low in group III but significantly high in group IV and not much significant differences were noticed in glucose concentrations among the groups. There was a significant (p<0.05) decrease in the uterine weights in group II. The liver lipid profile revealed significant (p<0.05) increase in total lipids, total cholesterol and phospholipids in group II compared to group I, where as they significantly (p<0.05) decreased in group III when compare to group II. The liver lipid profile of group III was almost similar to group IV. Triglyceride levels in the liver significantly (p<0.05) increased in group I than group II and III. Histopathological studies revealed fatty degeneration of liver, atrophy of uterus and mild sub-intimal fat accumulation in aorta of group II, where as these changes were ameliorated in group III.
In conclusion, the present study revealed that the germinated bengalgram seeds have significant hypolipidemic action and a significant (p<0.05) increase in the uterine weights in ovariectomized rats without any histopathological changes. This may be attributed to the presence of phytoestrogens in the germinated bengalgram seeds.
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Keywords
BENGALGRAM ;Cicer arientinum L.; HYPERLIPIDEMIAS; RATS