ESTROGEN RECEPTOR GENE POLYMORPHISM IN VECHUR AND CROSSBRED CATTLE OF KERALA

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dc.contributor.advisorK.A.Bindu
dc.contributor.authorKIRANA SASIDHARAN
dc.date.accessioned2020-07-10T07:35:08Z
dc.date.available2020-07-10T07:35:08Z
dc.date.issued2011
dc.description.abstractEstrogen receptor gene and pituitary specific transcription factor 1 gene was studied as candidates for genetic markers of milk production traits. The study was aimed to reveal the known variants at ESR/TspRI and PIT/HinfI locus in Vechur and crossbred cattle of Kerala and to analyze their association with milk production. The analysis of ESR/TspRI polymorphism revealed existence of three digestion patterns (CC, CA and AA) in Vechur and crossbred cattle. The A/C allele frequencies were 0.43/0.57 and 0.53/0.47, respectively in Vechur and crossbred cattle. The genotypes of ESR/TspRI polymorphism were distributed according to Hardy-Weinberg equilibrium with frequencies 0.33(CC), 0.47 (AC) and 0.20 (AA) in Vechur and 0.24 (CC), 0.46 (AC) and 0.30 (AA) in crossbred cattle under study. PCR-RFLP analysis of 451 bp fragment of PIT-1 gene revealed the predominance of BB genotype and B allele with a mean frequency of 0.57 and 0.75, respectively. AB genotype was the next most frequent with a mean frequency of 0.39. Only six individuals out of the 130 screened were observed to have AA genotype. Allele frequency at PIT/HinfI was the same in Vechur and its crossbred with Bos Taurus. Association studies revealed the significant influence of PIT/HinfI polymorphism on milk production traits. The A allele bearing Vechur and crossbred cattle showed an increase in 305 day milk yield and average daily milk yield. Lactation length in Vechur was significantly high for AA and AB genotype. ESR/TspRI showed no significant difference in milk yield. The selection of Vechur and crossbred cattle for A allele of PIT/HinfI polymorphism can significantly improve milk yield. This study validates the utility of PCR-RFLP as efficient means of exploring the distribution pattern of known variants at important candidate genes in the cattle population of Kerala for future breeding plans.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810148995
dc.keywordsESTROGEN RECEPTOR GENE POLYMORPHISM IN VECHUR CROSSBRED CATTLE KERALAen_US
dc.language.isoenen_US
dc.pages88en_US
dc.publisherCOLLEGE OF VETERINARY AND ANIMAL SCIENCES-MANNUTHY,THRISSURen_US
dc.research.problemESTROGEN RECEPTOR GENE POLYMORPHISM IN VECHUR AND CROSSBRED CATTLE OF KERALAen_US
dc.subAnimal Genetics and Breedingen_US
dc.subjectnullen_US
dc.themeESTROGEN RECEPTOR GENE POLYMORPHISM IN VECHUR AND CROSSBRED CATTLE OF KERALAen_US
dc.these.typeM.V.Sc.en_US
dc.titleESTROGEN RECEPTOR GENE POLYMORPHISM IN VECHUR AND CROSSBRED CATTLE OF KERALAen_US
dc.typeThesisen_US
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