IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH RECEPTOR AND PATHOLOGY OF ORAL AND PHARYNGEAL NEOPLASMS IN DOGS

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dc.contributor.advisorR., Anoopraj
dc.contributor.authorNAIK, MADHURA PRASHANT
dc.date.accessioned2021-01-07T06:14:42Z
dc.date.available2021-01-07T06:14:42Z
dc.date.issued2019-10-03
dc.description.abstractThe present study entitled “Immunohistochemical expression of epidermal growth factor receptor and pathology of oral and pharyngeal neoplasms in dogs” was conducted for obtaining the data on the occurrence of oral and pharyngeal neoplasms in dogs, classification and grading and to compare the expression of epidermal growth factor receptor expression in tumour and normal tissues. A total of 23 oral and pharyngeal lesions were recorded. Out of the 23 lesions, 20 cases were diagnosed as neoplasms and 3 cases were of non-neoplastic origin. Age groups of seven to nine years showed highest incidence of the tumour (45 per cent), 85 per cent of the affected animals were males, while Labrador was the most affected breed (35 per cent). Gingiva formed the common site affected with tumours (60 per cent). The occurrence of malignant and mesenchymal tumours was 55 per cent and 80 per cent respectively. The malignant tumours encountered were histiocytic sarcomas, squamous cell carcinoma, fibrosarcoma, hemangiosarcoma, telangiectatic osteosarcoma and melanoma. Benign tumours included peripheral odontogenic fibroma, osteoma, oral papilloma and fibroma. Malignant tumours were graded based on specific histopathological parameters. Three cases of gingival hyperplasia were also studied. Expression of epidermal growth factor receptor (EGFR) was assessed in tumour specimens and the corresponding normal tissues by immunohistochemistry. Archived samples such as basal cell carcinoma, squamous cell carcinoma, acanthomatous ameloblastoma, desmoplastic ameloblastoma, papilloma and melanoma were also included in the study. When compared to normal tissues, significant strong over expression of EGFR was observed in squamous cell carcinoma, basal cell carcinoma, histiocytic neoplasms, hemangiosarcoma and melanoma while fibrosarcoma and ameloblastoma showed moderate over expression. No significant difference in EGFR expression was observed in papilloma and bone tumours.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810159340
dc.keywordsEPIDEMIOLOGY,TUMOURS ,Immunohistochemistry, GROSS PATHOLOGY,HISTOPATHOLOGY ,Epidermal growth factor receptor 2,Vascular endothelial growth factor receptoren_US
dc.language.isoEnglishen_US
dc.pages92en_US
dc.publisherCOLLEGE OF VETERINARY AND ANIMAL SCIENCES, POOKODE WAYANADen_US
dc.research.problemEPIDERMAL GROWTH RECEPTOR AND PATHOLOGY OF ORAL AND PHARYNGEAL NEOPLASMS IN DOGSen_US
dc.subVeterinary Pathologyen_US
dc.themeIMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH RECEPTOR AND PATHOLOGY OF ORAL AND PHARYNGEAL NEOPLASMS IN DOGSen_US
dc.these.typeM.V.Sc.en_US
dc.titleIMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH RECEPTOR AND PATHOLOGY OF ORAL AND PHARYNGEAL NEOPLASMS IN DOGSen_US
dc.typeThesisen_US
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