IMMUNOHISTOCHEMICAL EXPRESSION OF EPIDERMAL GROWTH RECEPTOR AND PATHOLOGY OF ORAL AND PHARYNGEAL NEOPLASMS IN DOGS
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Date
2019-10-03
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COLLEGE OF VETERINARY AND ANIMAL SCIENCES, POOKODE WAYANAD
Abstract
The present study entitled “Immunohistochemical expression of epidermal
growth factor receptor and pathology of oral and pharyngeal neoplasms in dogs”
was conducted for obtaining the data on the occurrence of oral and pharyngeal
neoplasms in dogs, classification and grading and to compare the expression of
epidermal growth factor receptor expression in tumour and normal tissues. A total
of 23 oral and pharyngeal lesions were recorded. Out of the 23 lesions, 20 cases
were diagnosed as neoplasms and 3 cases were of non-neoplastic origin. Age groups
of seven to nine years showed highest incidence of the tumour (45 per cent), 85 per
cent of the affected animals were males, while Labrador was the most affected breed
(35 per cent). Gingiva formed the common site affected with tumours (60 per cent).
The occurrence of malignant and mesenchymal tumours was 55 per cent and 80 per
cent respectively. The malignant tumours encountered were histiocytic sarcomas,
squamous cell carcinoma, fibrosarcoma, hemangiosarcoma, telangiectatic
osteosarcoma and melanoma. Benign tumours included peripheral odontogenic
fibroma, osteoma, oral papilloma and fibroma. Malignant tumours were graded
based on specific histopathological parameters. Three cases of gingival hyperplasia
were also studied. Expression of epidermal growth factor receptor (EGFR) was
assessed in tumour specimens and the corresponding normal tissues by
immunohistochemistry. Archived samples such as basal cell carcinoma, squamous
cell carcinoma, acanthomatous ameloblastoma, desmoplastic ameloblastoma,
papilloma and melanoma were also included in the study. When compared to
normal tissues, significant strong over expression of EGFR was observed in
squamous cell carcinoma, basal cell carcinoma, histiocytic neoplasms,
hemangiosarcoma and melanoma while fibrosarcoma and ameloblastoma showed
moderate over expression. No significant difference in EGFR expression was
observed in papilloma and bone tumours.