Enrofloxacin induced oxidative stress in kidney homogenates of broilers and its amelioration with antioxidants vitamin e and alpha lipoic acid

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dc.contributor.authorElamaran, A
dc.contributor.authorRamesh, S
dc.contributor.authorVairamuthu, S
dc.contributor.authorTANUVAS
dc.date.accessioned2021-12-06T11:37:11Z
dc.date.available2021-12-06T11:37:11Z
dc.date.issued2018
dc.descriptionTNV_PIJ_2018_7(6)226-228en_US
dc.description.abstractThe experiment was conducted to evaluate the effect of enrofloxacin induced oxidative stress in kidney homogenates of broiler chickens. Total fifty broiler chickens divided into five groups at the age of day 38 were used for this study. Oxidative stress was produced in the chickens with Enrofloxacin at an oral dose of 10 mg/kg b.w. In Enrofloxacin (10 mg/kg b.w) treated group, there was a significant elevation in the oxidative biomarkers like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH) and marked increase in lipid peroxidation (MDA) of kidney homogenates. Treatment with either alpha-lipoic acid (100 mg/kg b.w) or vitamin E (100 mg/kg b.w) significantly restored the antioxidant status in Kidney homogenates. Whereas, co-treatment of alpha-lipoic acid (100 mg/kg b.w) and vitamin E (100 mg/kg b.w) had significantly restored the antioxidant parameters which are comparable with the normal control birds. Thus the results of this study suggest that enrofloxacin induced oxidative stress in broilers at the therapeutic doses can be effectively ameliorated by treating with vitamin E and alpha-lipoic acid combination than treating with either of these drugs alone.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810178696
dc.keywordsEnrofloxacin, alpha lipoic acid, vitamin- e, kidney homogenatesen_US
dc.language.isoEnglishen_US
dc.pages226-228en_US
dc.relation.ispartofseries;6
dc.subjectVeterinary Scienceen_US
dc.titleEnrofloxacin induced oxidative stress in kidney homogenates of broilers and its amelioration with antioxidants vitamin e and alpha lipoic aciden_US
dc.title.alternativeThe Pharma Innovation Journalen_US
dc.typeArticleen_US
dc.volume7en_US
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