Expression of hepcidin and ferroportin in full term swine placenta

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dc.contributor.authorRajamanickam, K
dc.contributor.authorLeela, V
dc.contributor.authorSuganya, G
dc.contributor.authorHayath Basha, Sabiha
dc.contributor.authorParthiban, M
dc.contributor.authorPazhanivel, N
dc.contributor.authorMangala Gowri, A
dc.contributor.authorTANUVAS
dc.date.accessioned2020-03-10T09:27:15Z
dc.date.available2020-03-10T09:27:15Z
dc.date.issued2020-02
dc.descriptionTNV_20thMVC_PP_Feb-2020_PA59en_US
dc.description.abstractIn swine, even though the pregnant sows were with iron abundance, the inborn iron reserve of piglets were compromised indicating the insufficiency of the molecular machinery involved in placental iron transfer from sow to fetus. Hepcidin and ferroportin are the two important peptides regulating systemic iron homeostasis. Hepcidin is synthesized from heptocytes in response to changes in iron level, inflammation and oxidative stress conditions. It controls the iron exportation from cells by acting on membrane iron exporter, ferroportin. Here we investigated, for the first time, the molecular and morphological expression of iron regulatory proteins like hepcidin and ferroportin in placenta of full term pregnant sows and their association with placental iron abundance. Presence of hepcidin and ferroportin sequence in placental DNA was confirmed through PCR and sequencing (Accession number: Hepcidin - MN579557, Ferroportin - MN565887). Hepcidin and ferroportin proteins have also been revealed by western blot analysis and immunohistochemistry. The immunoreactivity for both proteins was observed in the cytoplasm and membrane of the trophoblastic cells of the placenta. Placental mRNA abundance of hepcidin was associated with local stimuli of hepcidin production like oxidative stress and pro-inflammatory cytokines expression. Hepcidin expression was also positively associated with the placental non-heme iron reserve. This indicates that hepcidin has a role in materno-fetal iron transfer by controlling local iron flux. Further studies are warranted to elucidate the use of hepcidin and ferroportin for improving iron transfer to the developing fetus and thereby inborn iron reserve in piglets can be increased, which may prevent the incidence of piglet anaemia.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810145131
dc.keywords20th Indian Veterinary Congress, Annual Conference of IAAVR, TANUVASen_US
dc.language.isoenen_US
dc.pages1en_US
dc.subjectVeterinary Scienceen_US
dc.titleExpression of hepcidin and ferroportin in full term swine placentaen_US
dc.title.alternativeNational Symposium on Veterinary Research Priorities in Translational Animal Health, Production and Food Safetyen_US
dc.typePresentationen_US
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