Genotoxicity assessment of andrographolide in Ames mutagenicity assay and in vitro chromosomal aberration assay

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dc.contributor.authorSrinivasan, MR
dc.contributor.authorPreetha, SP
dc.contributor.authorSudhakar Rao, GV, et al.,
dc.contributor.authorTANUVAS
dc.date.accessioned2021-12-07T05:49:20Z
dc.date.available2021-12-07T05:49:20Z
dc.date.issued2021
dc.descriptionTNV_PIJ_2021_10(3)61-65en_US
dc.description.abstractAbstract Andrographis paniculata (Burm.f.) Nees. is a medicinal herb widely used in various traditional medicines for the treatment of various ailments particularly related to viral fever, respiratory tract infections, and other pharmacological properties. Andrographolide is a diterpene present as a major active ingredient responsible for various pharmacological activities. This study was conducted to assess the mutagenicity and clastogenicity potential of the andrographolide by Ames mutagenicity and in vitro chromosomal aberration studies, respectively. Materials and Methods: Ames Mutagenicity assay was performed using Salmonella typhimurium strains, TA100, TA1535, TA102 and TA98 and TA1537 and in vitro chromosomal aberration study was performed in CHO-K1 cell line. Both these studies were conducted following the procedure mentioned in the OECD guidelines no. 471 and 473 for Ames and in vitro chromosomal aberration studies, respectively. Results: Andrographolide was found to be non-mutagenic in Ames mutagenicity assay and non-clastogenic in the in vitro chromosomal aberration study in the CHO-K1 cell line.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810178720
dc.keywordsAndrographolide, Andrographis paniculata, genotoxicity, Ames, in vitro chromosomal aberrationen_US
dc.language.isoEnglishen_US
dc.pages61-65en_US
dc.relation.ispartofseries;3
dc.subjectVeterinary Scienceen_US
dc.titleGenotoxicity assessment of andrographolide in Ames mutagenicity assay and in vitro chromosomal aberration assayen_US
dc.title.alternativeThe Pharma Innovation Journalen_US
dc.typeArticleen_US
dc.volume10en_US
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