STUDIES ON THE ACTION OF BOERHAAVIA DIFFUSA LINN. AGAINST FURAZOLIDONE INDUCED HEPATOTOXICITY IN POULTRY
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Date
2003-09
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Sri Venkateswara Veterinary University, TIRUPATI – 517 502,A.P
Abstract
ABSTRACT :
Recent studies demonstrated the role of herbal drugs as hepatoprotectives by virtue of their antioxidant capacity. The present study was conducted to find out the protective and corrective effects of 60 % ethanolic extract of Boerhaavia diffusa Linn. and compare the same with that of silymarin on performance, clinical, biochemical and histopathological patterns in experimentally-induced oxidative damage by furazolidone to heart, kidney and liver in particular. One hundred and twenty, day-old Vencob broiler chicks were classified into six groups and experiment was conducted from 15th day: Group 1 served as vehicle control; Group 2, 5 and 6 received furazolidone at dose rate of 150 mg/kg body weight; Group 3 and 4, in addition to furazolidone, received oral doses of B.diffusa (200 mg/kg body weight) and silymarin (200 mg/kg body weight) respectively up to 4 weeks of age. Thereafter, Groups 3, 5 and 4, 6 received B.diffusa and silymarin respectively and Group 2 was left without any treatment till the end of the experiment (6th week).
Body weight gains and feed conversion ratio of the birds were recorded at weekly intervals to evaluate the performance of the birds. Profiles of liver (ALT, AST and LDH), kidney (uric acid), lipids (total cholesterol and HDL), proteins (total proteins, albumins and A/G ratio) and erythrocyte antioxidant enzyme profile (GPx and GSH-R), and hematological profile (Hb%, PCV, TEC, TLC, MCV, MCH and MCHC) were also assessed at weekly intervals. At the end of 4th and 6th weeks, the birds were sacrificed, liver was collected to assess the extent of lipid peroxidation, and liver, heart and kidney, were taken for organ-somatic indices and histopathological examination.
The studied parameters altered by furazolidone were significantly modulated by B.diffusa and silymarin, and histopathological examination showed that B.diffusa and silymarin ameliorated the degenerative changes caused by furazolidone in liver, heart and kidney. Treatment with B.diffusa and silymarin also significantly (p<0.05) reduced the toxic effect of furazolidone on malondialdehyde content.
It is concluded that administration of ethanolic extract of B.diffusa and silymarin could play an important role in protection, however, silymarin exhibited better corrective action compared to B.diffusa against oxidative damage and consequently liver damage caused by furazolidone-generated free radicals.
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Keywords
BOERHAAVIA DIFFUSA LINN; FURAZOLIDONE; HEPATOTOXICITY; POULTRY