Expression of Biomarkers in Canine Mammary Tumours

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dc.contributor.authorMuniappan, N
dc.contributor.authorRamesh, S
dc.contributor.authorHemalatha, S
dc.contributor.authorMohamed, Shafiuzama
dc.contributor.authorPreetha, SP
dc.contributor.authorTANUVAS
dc.date.accessioned2019-11-05T07:15:26Z
dc.date.available2019-11-05T07:15:26Z
dc.date.issued2019
dc.descriptionTNV_IJCMAS_2019_8(5)1464-1473en_US
dc.description.abstractBiomarkers identifiable in tumours have potential use in early diagnosis, staging, prognosis and assessment of response to therapy. This paper describes the immunohistochemical expression of a few reliable biomarkers in post surgical canine mammary gland tumour (CMGT). Immunohistochemical expression of biomarkers in canine mammary tumours was carried out in forty three mammectomised tissue samples. The intensity and distribution of immunostaining of the biomarkers in histological types of CMGT was studied. PCNA showed weak nuclear staining in benign tumour and strong nuclear staining in malignant tumours. Bcl 2 showed weak cytoplasmic staining in benign tumours and moderate cytoplasmic staining in 10-20% of epithelial cells in malignant tumours. Cytokeratin 8/18 expression was strong in >50% of epithelial cells in benign and malignant tumours. Vimentin expression was specific with strong cytoplasmic staining in the stromal fibrous tissue, stromal fusiform cells, myoepithelial cells in tubules, spindle cells, chondroid tissue and lipocytes. CEA expression was negative in benign tumours. Malignant tumours expressed moderate membranous to cytoplasmic staining in 10-20% of luminal epithelial cells. MUC 1 expression was weak membranous staining in <10% of apical portion of luminal epithelial cells in benign tumours. Overexpression of MUC 1 was observed as moderate membranous and cytoplasmic staining in 10-20% of luminal epithelial cells in malignant tumours. HER-2 expression was weak membrane staining in <10% of luminal epithelial cells in benign tumours. Moderate membranous and cytoplasmic staining was observed in 10-20% of luminal epithelial cells in malignant tumours. COX 2 enzyme expression was negative in benign tumours. Moderate cytoplasmic staining in 10-20% of luminal epithelial cells, myoepithelial cells, stromal fusiform cells and stromal inflammatory cells was observed in malignancy. Hence the expression of biomarkers in tissues is of diagnostic and prognostic significance before initiation of treatment regimen in canine mammary tumours.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810134301
dc.keywordsCanine mammary tumours, Biomarkers immnuno histochemistryen_US
dc.language.isoenen_US
dc.pages1464-1473en_US
dc.publisherExcellent Publishersen_US
dc.relation.ispartofseries;5
dc.subjectVeterinary Scienceen_US
dc.titleExpression of Biomarkers in Canine Mammary Tumoursen_US
dc.title.alternativeInternational Journal of Current Microbiology and Applied Sciencesen_US
dc.typeArticleen_US
dc.volume8en_US
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