Assessment of Role of Hepcidin in Inflammatory Condition in Canine Pyometra
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Date
2019-02
Journal Title
Journal ISSN
Volume Title
Publisher
Pashupati Foundation India
Abstract
Hepcidin is one of the great discovery in hematology, associated with iron homeostasis. It is a peptide of
25 amino acids and it is synthesized primarily in the liver, which has its synthesis linked to infections and
inflammations. Pyometra is a common reproductive disorder in the middle-aged bitches in diestrual phase
of estrous cycle when uterus is being exposed to high levels of progesterone. Pyometra is associated with
bacterial infection leading to endometritis and toxaemia. Pyometra develops as a result of complex
etiological factors which includes hormonal influence of uterine environment, virulence of the infecting
bacteria with concomitant disability of the bitches to combat the infection or its inflammatory products.
This accelerates the inflammatory process in the affected bitches and activates the macrophages to
scavenge the pathogenic bacteria. The present study was conducted to explore the role of hepcidin hormone
in mediating the inflammatory process in pyometra affected bitches. Blood samples were collected from ten
dogs with open type of pyometra and from ten apparently healthy dogs. Haematological parameters and
hepcidin were estimated in pyometra affected bitches and in control animals. Leucocytosis and neutrophilia
and their blood hepcidin hormone level were elevated when compared to apparently healthy dogs. This
shows that increase in hepcidin hormone is beneficial in mediating the inflammatory process because it
increases the intracellular iron content of macrophages which is needed for destruction of engulfed
pathogens.
Description
TNV_IJLR_2019_9(2)254-259
Keywords
Veterinary Science