Acute toxicity of Cleistanthus collinus : An indigenous poisonous plant in Cavia procellus
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Date
1998
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Abstract
Cleistanthus collinus, a highly toxic plant is commonly implicated in suicidal
and homicidal poisoning. Acute impact of C. collinus on glutathione and ATPase was
investigated in guinea pig, Cauia pracellus. Aqueous extract of C. collinus leaf was
administered orally at 24 h LD50 dose (316 mg/kg). There was a significant concomittant
depletion of glutathione and ATPase inhibition in vital organs. The toxic pertubation
of C. collinus is attributed to thiol/thiol dependent enzyme inhibition.
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Keywords
Veterinary Science, Veterinary Pharmacology and Toxicology