Diagnosis and immunohistochemical evaluation of equine preputial tumors
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Date
2022
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Abstract
Two geldings of eight and ten-year-old were presented to the Madras Veterinary College Teaching Hospital with tumor
mass on the preputial region. Microscopical examination of one of the preputial mass revealed the presence of loosely arranged
fi brovascular stoma with epidermal hyperplasia and hyperkeratosis. Finger like projections, rete pegs extend in to fi bromatous
tissue were noticed and identifi ed as fi bropapilloma. The second mass revealed polyhedral shaped cells with pale blue cytoplasm
and keratin pearls, suggestive of squamous cell carcinoma. On immunohistochemical study cytokeratin was expressed in both
tumors while vimentin expression was high in squamous cell carcinoma. E-cadherin was poorly expressed in squamous cell carcinoma
and intensely positive in Fibropapilloma. Based on histopathology and immunohistochemistry it was classifi ed as poorly
diff erentiated squamous cell carcinoma and prone to metastasis. The current fi ndings concluded a possible role of vimentin in
the development and progression of preputial tumour and vimentin and E-cadherin markers will be useful in the diagnosis and
prognosis of preputial skin neoplasms in equines.
Description
TNV_IJVP_2022_46(2)150-152
Keywords
Veterinary Science