EFFECT OF Trigonella foenum graecum (FENUGREEK) AGAINST HYPERLIPIDEMIAS IN OVARIECTOMIZED RATS
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Date
2010-07
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Sri Venkateswara Veterinary University, TIRUPATI – 517 502,A.P
Abstract
ABSTRACT :
Recognition of hypercholesterolemia as a risk factor for cardiovascular diseases leads to the development of drugs that reduce serum cholesterol levels. Plant kingdom is a rich natural source for many therapeutic molecules of which Trigonella foenum graecum (Fenugreek) seeds are reported to possess hypolipidemic activity in diet induced and diabetic induced models. However, no reports are available on the hypolipidemic potential of fenugreek in an ovariectomized rat model.
Experimental studies were conducted to evaluate the ameliorating effects of propanolic extract of Trigonella foenum graecum (Fenugreek) seeds in ovarian hormone deficiency induced hyperlipidemia in comparision with atorvastatin.
Thirty female wistar rats were divided into five groups i.e., group I – normal control (sham operated), group II – ovariectomized rats (OVX), group III – OVX+Fenugreek extract (1 g/kg b.wt), group IV – OVX+Fenugreek (4 g/kg b.wt) and OVX+Atorvastatin (1.2 mg/kg b.wt p.o.). Body weights were taken at weekly interval. Blood was collected from 8 h fasted animals on days 14, 28, 42 and 56 for the estimation of serum biochemical profile (Lipid profile and glucose). At the end of the experimental period, the rats were sacrificed
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Keywords
RATS; OVARIECTOMIZED RATS ; HYPERLIPIDEMIAS ;Trigonella foenum graecum; FENUGREEK; atorvastatin