MANAGEMENT OF OXIDATIVE STRESS IN CAPRINE ANAPLASMOSIS

Simple item page
dc.contributor.advisorUsha Narayana Pillai
dc.contributor.authorDHANASREE G.
dc.date.accessioned2022-11-01T07:17:36Z
dc.date.available2022-11-01T07:17:36Z
dc.date.issued2019-08-05
dc.descriptionSubmitted in partial fulfillment of requirement for the degree of Master of Veterinary Science in Veterinary Clinical Medicine, Ethics and Jurisprudenceen_US
dc.description.abstractCaprine anaplasmosis is an economically important tick-borne rickettsial disease that affects goats all over the world. The present study entitled “Management of oxidative stress in caprine anaplasmosis” apprehends the correlation between parasitemia caused by Anaplasma spp. and oxidative stress indices and also the management of oxidative stress in goats affected with anaplasmosis. Microscopic examination of stained blood smears from 162 animals revealed inclusion bodies of Anaplasma spp. in 24 cases. Genus specific PCR for Anaplasma spp. yielded positive results in 22 cases and 10 in-contact animals. Major clinical signs noted were anorexia, pyrexia, dullness, pallor of mucous membrane, drop in milk yield , diarrhoea and wasting. Haematological analysis revealed anaemia with low TEC, Hb and VPRC. All the diseased animals showed a significant fall in the mean values of antioxidants such as reduced glutathione, superoxide dismutase and catalase and a significant increase in the level of lipid peroxidation. It was found that the parasitemia and malondialdehyde levels were in positive correlation whereas all the antioxidants were in negative correlation with parsitemia. Out of the 22 animals positive for anaplasmosis both in blood smear and PCR, 16 female non pregnant goats selected for study were divided into two groups consisting of eight animals each. Animals belonging to group I and II were treated with oxytetracycline dihydrate. In addition, animals of group II were supplemented with vitamin E- selenium combination. Haematological and oxidative stress parameters were rechecked on 10th day of treatment. Clinical response and improvement in haematological parameters were equally evident in both the groups. At the end of the study period, a significant reduction in malondialdehyde level and a significant increase in mean value of superoxide dismutase were detected in group II. While there was a significant reduction in lipid peroxidation and a significant increase in superoxide dismutase and catalase values within both the groups after treatment, reduced glutathione showed no significant difference within the group.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810189491
dc.keywordsGoats, livelihood, marginal farmers, Anaplasmosis , Oxidative stress, Vitamin E and Selenium, parasitemia, Polymerase Chain Reaction , Tris EDTA borate buffer (TBE), Ethidium bromide stock solution , Haemaphysalis bispinosa, Rhipicephalus sanguineus,en_US
dc.language.isoEnglishen_US
dc.pages132p.en_US
dc.publisherCOLLEGE OF VETRINARY AND ANIMAL SCIENCES MANNUTHY, THRISSURen_US
dc.research.problemEvaluation of markers of oxidative stress in caprine anaplasmosis , Assessment of relationship between parasitemia and stress parameters , Assessment of therapeutic responseen_US
dc.subClinical Veterinary Medicine, Ethics and Jurisprudenceen_US
dc.themeOXIDATIVE STRESS IN CAPRINE ANAPLASMOSISen_US
dc.these.typeM.V.Sc.en_US
dc.titleMANAGEMENT OF OXIDATIVE STRESS IN CAPRINE ANAPLASMOSISen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
DHANASREE G. FINAL THESIS.pdf
Size:
2.71 MB
Format:
Adobe Portable Document Format
Description:
Thesis: MANAGEMENT OF OXIDATIVE STRESS IN CAPRINE ANAPLASMOSIS
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Thesis