Hepatoprotective Effect of Aqueous Extract of Gyrocarpus asiaticus on Paracetamol Induced Hepatotoxicity in Zebra Fish

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dc.contributor.authorBaisakhi, Moharana
dc.contributor.authorPreetha, SP
dc.contributor.authorBalachandran, C
dc.contributor.authorAcharya, P
dc.contributor.authorTANUVAS
dc.date.accessioned2019-11-05T11:30:09Z
dc.date.available2019-11-05T11:30:09Z
dc.date.issued2019
dc.descriptionTNV_IJCMAS_2019_8(4)2260-2265en_US
dc.description.abstractParacetamol induced hepatotoxicity is a common model for accessing the hepatoprotective nature of new molecules. This study was conducted to evaluate the potential of aqueous extract of Gyrocarpus asiaticus on paracetamol induced hepatotoxicity in zebra fish. Fish were challenged with 20mM concentration of paracetamol followed by treatment with aqueous extract of Gyrocarpus asiaticus. Serum was evaluated for alanine transferase (ALT) concentration and liver samples were collected for histopathological analysis. Result of this study showed that, there was marked elevation of ALT in induced group and compare to paracetamol induced toxicity group, Gyrocarpus asiaticus treated group has got marked reduction in ALT which also confirmed through histopathological analysis, where the treatment group showed normal morphological features. Hence further study can be done to elucidate the mechanism of action of Gyrocarpus asiaticus through molecular level to have a confirmation of hepatoprotective nature of this plant.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810134409
dc.keywordsParacetamol, hepatotoxicity, Gyrocarpus asiaticus, zebra fish, ALTen_US
dc.language.isoenen_US
dc.pages2260-2265en_US
dc.publisherExcellent Publishersen_US
dc.relation.ispartofseries;4
dc.subjectVeterinary Scienceen_US
dc.titleHepatoprotective Effect of Aqueous Extract of Gyrocarpus asiaticus on Paracetamol Induced Hepatotoxicity in Zebra Fishen_US
dc.title.alternativeInternational Journal of Current Microbiology and Applied Sciencesen_US
dc.typeArticleen_US
dc.volume8en_US
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