STUDIES ON THE EFFICACY OF DETOMIDINE AND BUPRENORPHINE AS PREMEDICANTS TO PROPOFOL ANAESTHESIA IN GOATS

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dc.contributor.advisorDewangan, Rukmani
dc.contributor.authorSINGH MARAVI, MAHAJAN
dc.date.accessioned2018-01-06T09:21:08Z
dc.date.available2018-01-06T09:21:08Z
dc.date.issued2016
dc.description.abstractThe present study was undertaken to evaluate the efficacy of propofol in combination with premedicants like detomidine and buprenorphine for inducing general anaesthesia in goats. The experimental work was divided into three groups. Each group comprised of six healthy non-descript goats of either sex weighing between 20-25 kg. The animals were fasted for overnight and the drinking water was withheld for 4 hours before the administration of anaesthesia. A pilot study for standardization of the dose was conducted and the minimum effective dose was selected for the study. In group A, animals were premedicated with atropine sulphate @ 0.04 mg/kg b.wt and 10 min. later propofol will be @ 5mg/kg body wt. by slow intravenous injection. In group B, animals were premedicated with atropine sulphate @ 0.04 mg/kg b.wt followed by detomidine @ 15 μg/kg body wt.I/M. This was followed 10 min. later by intravenous injection of propofol @ 5mg/kg body wt. In group C, animals were premedicated with atropine sulphate @ 0.04 mg/kg body wt followed by buprenorphine @ 0.01 mg/kg body wt. I/M which was followed 10 min. later by intravenous injection of propofol @ 5mg/kg body wt. The onset of anaesthesia, duration of anaesthesia, extent of muscle relaxation, complete recovery and presence or absence of pedal reflexes and relaxation of anal sphincter were monitored in all the three groups. Physiological parameters viz. rectal temperature, heart rate, respiration rate were recorded before and 10 minutes after premedication and 10, 20, 40, 60, 90, 120 and 180 minutes after anaesthesia. Haematological parameters viz- Hb, PCV, TLC and DLC and biochemical parameters viz- serum glucose, serum urea nitrogen, creatinine, ALT and AST were estimated before premedication and at 30, 60, 120 minutes and 6 hrs. post anaesthesia. The onset of anaesthesia was quicker in group B as compared to group A and C. Duration of anaesthesia in group B was significantly (P<0.01) longer (52.33 ± 8.44 min.) than group A (16.31 ±1.29 min.) and group C (31.33 ± 1.20 min.). The time taken for complete recovery was significantly (P<0.01) longer in group B (91.66±14.24min.) as compared to group A (27.33±2.04 min) and group C (60.00±2.58min). The extent of muscle relaxation was excellent in group B, good in group C and poor in group A. The mean rectal temperature decreased non-significantly in animals of group A and C, upto 30 min. and 60 min. respectively. But, in group B, a non-significant decrease in the rectal temperature was observed after administration of propofol in combination with detomidine which persisted upto 90 min. The mean respiration rate decreased significantly (P<0.05) in group A from base value to 60 min. post anaesthesia in response to administration of propofol alone. Similarly, in group B, a significant (P<0.05) decrease in respiration was observed from base value upto 120 min. which become highly significant (P<0.01) at 60 min. In group C, a significant (P<0.05) decrease in respiration rate was observed at 30 min. These, values increased and returned to preadministration level by 180 min. There was a significant (P< 0.05) decrease in heart rate from base value upto 60 min. after propofol administration in group A. Later on, the values increased and returned to near normalcy by 180 min. In group B, a highly significant (P<0.01) decrease in heart rate was observed from base value upto 120 min after the administration of detomidine-propofol with a peak decrease at 60 min. However, the values increased and returned to preadministration level by 180 min. In group C, a significant (P<0.05) decrease was observed with a peak decrease at 30 minutes after administration of buprenorphine-propofol. However, the values were compensated and returned towards preadministration level by 180. Haematological studies revealed non-significant changes in Hb, PCV, and TLC at various time intervals after various treatments in all the three groups. While in DLC, there was significant (P<0.05) increase in neutrophils in group A, B and C at 60 minutes with significant (P<0.05) decrease in lymphocyte count at 60 in group A, B and C. However, the values returned to near normalcy at 6 hr of the study period in all the three groups. Monocytes showed a non-significant decrease in group A, B and C. Whereas, eosinphil counts showed a non-significant increase in group A, B and C. These values returned to near baseline up to 6 hr of the study period. Among biochemical parameters serum glucose showed a significant (P<0.05) increase in all the groups initially which returned to base values by 6 hrs of the study period. Serum urea nitrogen level showed a non significant changes in group A while, in animals of group B and C a significant (P<0.05) changes was observed at 60 min. Creatinine level showed non-significant changes in group A, B and C at various time intervals. Serum enzyme viz. AST values showed a significant (P<0.05) increase in group B only whereas, in group A and C, the increase was very marginal change was observed. ALT showed a significant (P<0.05) increase in group A, B and C was recorded. However, all the biochemical values were compensated and returned towards preadministration level by 6 hrs in all the three groups. On the basis of this study, it was concluded that propofol alone or in combination with detomidine and buprenorphine can be safely used as a general anaesthetic in goats. However, the changes observed during the observation period were transient, well tolerated by the animals and returned to their preadministration level within the study period. The combination of detomidine and propofol was proved to be better as it produced profound analgesia with quicker onset and of longer duration with excellent muscle relaxation alongwith smooth and uneventful recovery.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810038920
dc.language.isoenen_US
dc.publisherChhattisgarh Kamdhenu Vishwavidyalaya, Durgen_US
dc.subVeterinary Surgery and Radiologyen_US
dc.subjectnullen_US
dc.themeSTUDIES ON THE EFFICACY OF DETOMIDINE AND BUPRENORPHINE AS PREMEDICANTS TO PROPOFOL ANAESTHESIA IN GOATSen_US
dc.these.typeM.V.Sc.en_US
dc.titleSTUDIES ON THE EFFICACY OF DETOMIDINE AND BUPRENORPHINE AS PREMEDICANTS TO PROPOFOL ANAESTHESIA IN GOATSen_US
dc.typeThesisen_US
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