THERAPEUTIC EVALUATION OF SEABUCKTHORN (HIPPOPHAE SALICIFOLIA) FOR GASTRIC ULCERATION AND EROSIONS IN DOGS
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Date
2015-08-10
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CSKHPKV, Palampur
Abstract
The study was conducted in 2 phase on 16 healthy medium sized adult mongrel dogs divided into 4 equal groups. In phase 1, inj. Dexamethasone @1mg/kg, IV, bid was administered in all the animals until desired severity GUE indices were achieved. Thereafter, in Phase 2 animals were subjected to test treatments of seabuckthorn (Hippophae salicifolia) seed oil @ 1ml/dog, Aloe vera @10ml/dog and rabeprazole 1mg/kg body weight (minimum 20mg/dog) p.o., b.i.d. in different groups till the complete healing of GUE lesions was observed endoscopically. One group was kept as untreated control. The progression of GUE was evaluated on the basis of gastro-endoscopic, clinical, hematological, faecal occult blood test and biochemical examinations at regular intervals.
In phase 1, the gastro-endoscopic examinations revealed that by day 13, 62.5% dogs achieved the desired GUE index. Clinical parameters remains within the normal range with slight fluctuations but haematological parameter showed significant decrease in Hb, PCV, TEC, monocytes and lymphocytes whereas, TLC and granulocytes increased significantly. Body weight decreased in all the dogs. There was direct correlation between presence of gastric bleeding on endoscopic examination and positive fecal occult blood test. Subjective assessment revealed general lack of activities, reduced appetite and occasional vomiting (n=3/16).
In phase 2, the mean healing period of GUE was shortest in group 4 at 8.25 days followed by group 2 at 9 days, group 1 at 9.75 days and group 3 at 13.50 days. Qualitatively, the gastric mucosa was distinctively shiny and healthier in animals treated with rabeprazole and seed oil of Hippophae salicifolia. Clinical and haematological parameters showed marked improvement towards the end of phase 2. Faecal occult blood test was positive in all animals till there was endoscopic evidence of bleeding from the gastric ulcers. Blood urea nitrogen, total protein and creatinine remained within normal physiological limits throughout the study.
It is concluded that Rabeprazole and seed oil of Hippophae salicifolia have therapeutic efficacies in management of dexamethasone-induced GUE in dogs and they also help in restoration of gastric mucus layer in a faster manner. Whereas, Aloe vera treatment actually delayed the healing period of GUE.
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