STUDIES ON THE EFFECT OF Carica papaya L. SEEDS ON FERTILITY OF FEMALE BLACK RAT, Rattus rattus L.
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Date
2019-08-29
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UNIVERSITY OF AGRICULTURAL SCIENCES GKVK, BENGALURU
Abstract
During the investigation at AINP on VPM, Dept of Agricultural Entomology UAS,
Bengaluru, the black rat females were fed with papaya seeds powder at 0.75 g (3%), 1.25
g (5%) and 1.75 g (7%) with 25 g normal bait (10g rice + 10 g ragi + 2.5 g ground nut oil
+ 2.5 g jaggery) for 7, 15 and 30 days continuously in a separate cages. The results of the
investigation indicated that 1.25 g papaya seed powder with normal bait for 30 days (T6)
and 1.75 g for 15 (T8) and 30 days (T9) along with the normal bait were found to be effective
in inducing sterility by significantly enhancing diestrus stage of the estrus cycle. The same
treatments altered the cholesterol and glucose contents of serum. Besides these treatments
also reduced the FSH and LH, which play a key role in regulation of folliculogenesis. The
estradiol and progesterone levels of serum hormonal profiles of tested rats were also
declined significantly which affects the development of zygote. In the same treatments the
mating success was reduced to 33 per cent and 25-33 per cent of resulted pups survived up
to 40 days compared to control with 52.38 per cent. In treated rodents, histology of ovary
showed reduced number of graafian follicles, congestion and reduction in the number of
ovarian follicles. Further studies are required for understanding the establishment of exact
mechanism of action at cellular and molecular level that needs to be explored.