Effect of Esterified Glucomannan in Amelioration of Aflatoxin Induced Microscopic Changes in Broiler Chicks
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Date
2014-10
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Abstract
A biological experiment was conducted to evaluate the efficacy of
esterified glucomannan in counteracting aflatoxicosisin broiler chicks. The
chicks were given aflatoxin (AF) free diet oraflatoxin (1ppm) containing
diet or aflatoxin (1ppm) with esterified glucomannan (EG, 0.1%)
containing diet continuously from day-old to six weeks of age. At the end
of the study, the liver, kidneys, spleen and bursa of Fabricius were collected
for histopathological studies. Microscopically, the liver of the AF fed
broilers showed fatty change, degeneration and necrosis of hepatocytes and
the cellular infiltration around the portal triads and blood vessels. Kidneys
of AF intoxicated birds revealed degeneration and necrosis of tubular
epithelial cells along with cellular infiltration, congestion and haemorrhages
in the parenchyma, severe fatty change and mild infiltration of lymphoid
cells in the interstitial spaces. In spleen, congestion, multifocal areas of
haemorrhages and mild lymphocytic activity of periarteriolar lymphatic
tissue with increased number of histiocytes were observed in AF fed birds.
Mild to moderate degree of congestion, increased number of histiocytes
with heterophil infiltration, connective tissue proliferation, sparse
cellularity of the follicles with presence of large number of histiocytes
containing cellular debris were observed in bursa of Fabricius of AF treated
birds. Feeding of EG along with AF showed milder bile duct hyperplasia
and hypertrophy in liver and lowered the severity of tubular necrosis in
kidneys. However, supplementation of EG has no recognizable
counteracting effect on histopathology of spleen. Moderate degree of
lymphoid hyperplasia in bursa of Fabricius in broilers receiving both AF
and EG compared to AF alone treated group is indicative of ameliorative
action of EG.
Description
TNV_JPST_2014_2(4)69-74
Keywords
Veterinary Science