PHARMACOKINETIC STUDIES ON BETAINE IN BROILER CHICKENS INFECTED WITH COCCIDIA
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Date
2018-04
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
ABSTRACT:
Betaine is a commercially used anti coccidial agent in poultry. Present
study was aimed to know the pharmacokinetics of betaine hydrochloride in
healthy and coccidia infected birds. Three week old birds were divided into three
groups of five birds each. Group I and II consisted of normal healthy birds, while
group III birds were experimentally infected with coccidia before the
commencement of study. Group II and III birds received betaine hydrochloride
@ 100 mg.kg-1 orally once, while group I birds received dextrose normal saline
(DNS). Blood samples were collected from all the birds at pre determined time
intervals to know the plasma concentration of betaine and to calculate various pharmacokinetic parameters using PKSolver, version.2.0. Betaine concentration
ranged from 0.298±0.017 to 0.504±0.0115 mg.ml-1 and these represent the
endogenous betaine levels. In group II healthy birds that received betaine
hydrochloride once orally, plasma betaine concentration ranged from
0.455±0.041 to 1.186±0.204 mg.ml-1, while in group III coccidia infected birds it
ranged from 0.435±0.088 to 1.233±0.264 mg.ml-1. The analysis of plasma
concentration versus time data revealed that the AUC0-t and AUMC0-t values in
healthy and coccidia infected birds were 11.138±1.54 mg.mL-1*h and
66.60±8.26 mg.mL-1*h2 while in coccidia infected birds they were
8.653±0.91 mg.mL-1*h and 45.49±4.54 mg.mL-1*h2 with non-significant
difference. However MRT, t1/2 were found significantly decreased in coccidia
infected birds (5.28±0.165 h; 3.66±0.11 h) compared to those observed in
healthy birds (6.06±0.14 h; 4.20±0.101 h). The ß was observed to be
significantly increased in coccidia infected birds (0.190±0.006 h-1) compared to
that of healthy birds (0.16±0.003 h-1). The study further revealed increased Vdss
(0.65±0.082 L.kg-1) and ClB (0.122±0.014 L.kg-1h-1) value in coccidia infected
birds compared to healthy birds (0.636±0.13 L.kg-1; 0.102±0.01 L.kg-1h-1). The
study revealed that presence of coccidial infection significantly altered the
pharmacokinetics of orally administered betaine in poultry.
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